public void InitializeSet()
{
RunQuery(delegate
{
var speciesList = SpeciesList;
wstate.speciesList = speciesList.Select(s=>s.compactName).ToArray();
using (var strdb = new StringDatabaseSearch())
{
wstate.set = PartList.BuildInteractionSet(wstate.partList.parts.Where(p => p.enabled));
foreach (Protein prot in wstate.set.proteins.Values)
if (prot.stringID == 0)
strdb.UpdateProtein(prot);
}
Invoke(new Action(delegate {
comboSpecies.Items.AddRange(speciesList);
comboSpecies.SelectedIndex = Array.IndexOf(speciesList,
speciesList.FirstOrDefault(s => s.speciesId == 83333));
foreach (Protein prot in wstate.set.proteins.Values)
treeView.Nodes.Add(CreateProteinNode(prot));
treeView.ExpandAll();
}));
});
}
private void buttonMapInteractions_Click(object sender, EventArgs e)
{
var species = (StringDatabaseSearch.dbSpecies)comboSpecies.SelectedItem;
int speciesID = species.speciesId;
RunQuery(delegate
{
NativeExtend();
List<Protein> natives = new List<Protein>();
foreach (Protein p in wstate.set.proteins.Values)
if (!p.fromHomolog)
natives.Add(p);
using (StringDatabaseSearch strdb = new StringDatabaseSearch())
{
strdb.ExtendBestHomologs(wstate.set, natives, speciesID, 0, TreeUpdateLogCallback);
}
});
}
private void NativeExtend()
{
using (StringDatabaseSearch strdb = new StringDatabaseSearch())
{
strdb.ExtendInteractions(wstate.set, wstate.set.proteins.Values.Where(p => !p.fromHomolog).ToArray(),
MinInteractionScore, true, TreeUpdateLogCallback);
// Find the interactions between the newly added nodes
// strdb.ExtendInteractions(wstate.set, wstate.set.proteins.Values.Where(p => !p.fromHomolog).ToArray(),
// MinInteractionScore, false, TreeUpdateLogCallback);
}
}
private void buttonLocalExtend_Click(object sender, EventArgs e)
{
RunQuery(delegate
{
using (StringDatabaseSearch strdb = new StringDatabaseSearch())
{
strdb.ExtendInteractions(wstate.set, wstate.set.proteins.Values.Where(p => p.fromHomolog),
MinInteractionScore, true, TreeUpdateLogCallback);
}
});
}
