public static Cell XLGetCell(SpreadsheetDocument document, Sheet theSheet, string columnName, uint rowIndex) { WorkbookPart wbPart = document.WorkbookPart; // Retrieve a reference to the worksheet part. WorksheetPart wsPart = theSheet.XLPart(wbPart); // Use its Worksheet property to get a reference to the cell // whose address matches the address you supplied. string addressName = columnName + rowIndex; Cell theCell = wsPart.Worksheet.Descendants<Cell>().Where(c => c.CellReference == addressName).FirstOrDefault(); return theCell; }