Example #1
0
        public override void GlobalContext()
        {
            base.GlobalContext();
            _transporterContainerTemplateRepository = IoC.Resolve <ITransporterContainerTemplateRepository>();
            var allTransporters = _transporterContainerTemplateRepository.TransportersFor(_individual.Species.Name, CoreConstants.Organ.Brain);

            var influxBBB = allTransporters.Where(x => x.MembraneLocation == MembraneLocation.BloodBrainBarrier)
                            .FirstOrDefault(x => x.TransportType == TransportType.Influx);

            _transporter = _transporterFactory.CreateFor(_individual).DowncastTo <IndividualTransporter>().WithName("TRANS");
            var transportContainer = _transporter.ExpressionContainer(CoreConstants.Organ.Brain).DowncastTo <TransporterExpressionContainer>();

            transportContainer.UpdatePropertiesFrom(influxBBB);
            _individual.AddMolecule(_transporter);
            _transportProcess = _cloneManager.Clone(_compoundProcessRepository.ProcessByName(CoreConstantsForSpecs.Process.ACTIVE_TRANSPORT_SPECIFIC_MM)
                                                    .DowncastTo <PartialProcess>());
            _transportProcess.Name = "My Transport Process";
            _compound.AddProcess(_transportProcess);

            _simulation = DomainFactoryForSpecs.CreateModelLessSimulationWith(_individual, _compound, _protocol)
                          .DowncastTo <IndividualSimulation>();

            _simulation.CompoundPropertiesList.First()
            .Processes
            .TransportAndExcretionSelection
            .AddPartialProcessSelection(new EnzymaticProcessSelection {
                CompoundName = _compound.Name, ProcessName = _transportProcess.Name, MoleculeName = _transporter.Name
            });

            DomainFactoryForSpecs.AddModelToSimulation(_simulation);
        }
Example #2
0
 public void should_add_the_relative_expression_to_periportal_and_pericentral_and_set_the_value_to_100()
 {
     _undefined.ExpressionContainer(CoreConstants.Compartment.Pericentral).RelativeExpression.ShouldBeEqualTo(100);
     _undefined.ExpressionContainer(CoreConstants.Compartment.Periportal).RelativeExpression.ShouldBeEqualTo(100);
 }