public IndividualSimulation CreateForDDIRatio(IndividualSimulation originalSimulation)
{
//DDI Ratio=> manipulate inhibition parameters so that all DDI effects are effectively deactivated
var ddiRatioSimulation = createModelLessSimulationBasedOn(originalSimulation);
_simulationModelCreator.CreateModelFor(ddiRatioSimulation);
//now update all parameters from the orginal simulation
_simulationParametersUpdater.ReconciliateSimulationParametersBetween(originalSimulation, ddiRatioSimulation);
_interactionTask.AllInteractionContainers(ddiRatioSimulation)
.SelectMany(c => c.AllParameters())
.Each(p => p.Value = disabledDDIValueFor(p.Name));
return(ddiRatioSimulation);
}
public IndividualSimulation CreateForDDIRatio(IndividualSimulation originalSimulation)
{
//DDI Ratio=> manipulate inhibition parameters so that all DDI effects are effectively deactivated
var ddiRatioSimulation = createModelLessSimulationBasedOn(originalSimulation);
_simulationModelCreator.CreateModelFor(ddiRatioSimulation);
// now update all parameters from the original simulation. We need to take protocol parameters as well as simulation parameters into account for the update
// as simulation building block are all kept in sync with the changes values EXCEPT Protocol (1 to n mapping)
_simulationParametersUpdater.ReconciliateSimulationParametersBetween(originalSimulation, ddiRatioSimulation, PKSimBuildingBlockType.Simulation | PKSimBuildingBlockType.Protocol);
_interactionTask.AllInteractionContainers(ddiRatioSimulation)
.SelectMany(c => c.AllParameters())
.Each(p => p.Value = disabledDDIValueFor(p.Name));
return(ddiRatioSimulation);
}
public IndividualSimulation CreateForBioAvailability(Protocol ivProtocol, Compound compound, IndividualSimulation originalSimulation)
{
return(createForPKCalculation(originalSimulation, compound, (pkSimulation, pkCompound, allProtocols) =>
{
var protocolProperties = pkSimulation.CompoundPropertiesFor(pkCompound).ProtocolProperties;
//remove old protocol used by compound and replace with new one
allProtocols.Remove(protocolProperties.Protocol);
allProtocols.Add(ivProtocol);
protocolProperties.Protocol = ivProtocol;
}));
}
private void updateAucIVCacheFrom(IndividualSimulation sourceSimulation)
{
ClearPKCache();
sourceSimulation.AllCompoundPK.Each(AddCompoundPK);
}
