protected override void Context()
{
sut = new UserDefinedPKParameter();
_options = new PKCalculationOptions {
TotalDrugMassPerBodyWeight = 20
};
_interval0 = new DosingInterval {
DrugMassPerBodyWeight = 2
};
_interval1 = new DosingInterval {
DrugMassPerBodyWeight = 3
};
_interval2 = new DosingInterval {
DrugMassPerBodyWeight = 4
};
_interval3 = new DosingInterval {
DrugMassPerBodyWeight = 5
};
_interval4 = new DosingInterval {
DrugMassPerBodyWeight = 6
};
_options.AddInterval(_interval0);
_options.AddInterval(_interval1);
_options.AddInterval(_interval2);
_options.AddInterval(_interval3);
_options.AddInterval(_interval4);
}
public override void GlobalContext()
{
base.GlobalContext();
_multipleDosingColumn = DataColumnLoader.GetDataColumnFrom("MultipleDosing_0_8_16");
_pkOptions = new PKCalculationOptions
{
TotalDrugMassPerBodyWeight = 10,
};
_pkOptions.AddInterval(new DosingInterval {
StartValue = 0, EndValue = 8, DrugMassPerBodyWeight = _firstDose
});
_pkOptions.AddInterval(new DosingInterval {
StartValue = 8, EndValue = 16, DrugMassPerBodyWeight = _oneMinusLastDose
});
_pkOptions.AddInterval(new DosingInterval {
StartValue = 16, EndValue = 48, DrugMassPerBodyWeight = _lastDose
});
_cmax_tD1_tD2 = new UserDefinedPKParameter {
StartApplicationIndex = 0, EndApplicationIndex = 1, StandardPKParameter = StandardPKParameter.C_max, Name = "MyCmaxD1D2"
};
_cmax_tD1_tD2_DOSE_BW = new UserDefinedPKParameter {
StartApplicationIndex = 0, EndApplicationIndex = 1, StandardPKParameter = StandardPKParameter.C_max, Name = "MyCmaxD1D2_Normalized", NormalizationFactor = _firstDose
};
_cmax_tD1_tD2_DOSE_BW_auto = new UserDefinedPKParameter {
StartApplicationIndex = 0, EndApplicationIndex = 1, StandardPKParameter = StandardPKParameter.C_max_norm, Name = "MyCmaxD1D2_Normalized_auto"
};
_tmax_tD1_tD2 = new UserDefinedPKParameter {
StartApplicationIndex = 0, EndApplicationIndex = 1, StandardPKParameter = StandardPKParameter.t_max, Name = "MyTmaxD1D2"
};
_cmax_t1_t2 = new UserDefinedPKParameter {
StartTime = 0, EndTime = 8, StandardPKParameter = StandardPKParameter.C_max, Name = "MyCmaxT1T2"
};
_cmax_t1_t2_offset = new UserDefinedPKParameter {
StartTime = 0, StartTimeOffset = 16, EndTime = 48, StandardPKParameter = StandardPKParameter.C_max, Name = "MyCmaxT1T2offset"
};
_cmax_t1_offset_no_end = new UserDefinedPKParameter {
StartTime = 0, StartTimeOffset = 16, StandardPKParameter = StandardPKParameter.C_max, Name = "MyCmaxT1offset_no_end"
};
_tThreshold = new UserDefinedPKParameter {
StartApplicationIndex = 0, StandardPKParameter = StandardPKParameter.Tthreshold, Name = "Threshold", ConcentrationThreshold = 4
};
_tThreshold_last = new UserDefinedPKParameter {
StartApplicationIndex = 2, StandardPKParameter = StandardPKParameter.Tthreshold, Name = "Threshold_last", ConcentrationThreshold = 5
};
_allDynamicPkParameters = new[] { _cmax_tD1_tD2, _tmax_tD1_tD2, _cmax_t1_t2, _cmax_t1_t2_offset, _cmax_t1_offset_no_end, _cmax_tD1_tD2_DOSE_BW, _tThreshold, _tThreshold_last, _cmax_tD1_tD2_DOSE_BW_auto };
}
public override void GlobalContext()
{
base.GlobalContext();
_multipleDosingColumn = DataColumnLoader.GetDataColumnFrom("MultipleDosing_0_8_16");
_pkOptions = new PKCalculationOptions
{
TotalDrugMassPerBodyWeight = 10,
};
_pkOptions.AddInterval(new DosingInterval {
StartValue = 0, EndValue = 8, DrugMassPerBodyWeight = _firstDose
});
_pkOptions.AddInterval(new DosingInterval {
StartValue = 8, EndValue = 16, DrugMassPerBodyWeight = _oneMinusLastDose
});
_pkOptions.AddInterval(new DosingInterval {
StartValue = 16, EndValue = 48, DrugMassPerBodyWeight = _lastDose
});
}