private void lvPeptides_ItemChecked(object sender, ItemCheckedEventArgs e)
        {
            if (this.bUpdatingPeptide)
            {
                return;
            }

            if (e.Item == null)
            {
                return;
            }

            var spectrum = e.Item.Tag as IIdentifiedSpectrum;

            option.SetPeptideRatioValid(spectrum, e.Item.Checked);

            UpdatePeptideColor(spectrum, e.Item);

            UpdateProteinContainsPeptide(spectrum);

            DoUpdateResult();

            DoUpdateProtein();

            this.btnSave.Enabled = true;
        }