public void ValidateDerivedSequenceConvertToString() { string seqLargeStr = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeStringNode); ISequence seqLarge = new Sequence(Alphabets.DNA, seqLargeStr); ISequence DeriveSeqLarge = new DerivedSequence(seqLarge, false, true); string ActualLargeString = DeriveSeqLarge.ToString(); string seqLargeExpected = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeExpectedNode); string expectedLargeString = string.Format(CultureInfo.CurrentCulture, seqLargeExpected, (seqLarge.Count - Helper.AlphabetsToShowInToString)); Assert.AreEqual(expectedLargeString, ActualLargeString); // Get input and expected values from xml string expectedSequence = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.AlphabetNameNode); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence ISequence seq = new Sequence(alphabet, expectedSequence); var derSequence = new DerivedSequence(seq, false, false); Assert.AreEqual(expectedSequence.Substring(2, 5), derSequence.ConvertToString(2, 5)); }
public void ValidateDnaDerivedSequenceIndexOfNonGap() { // Get input and expected values from xml string expectedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.AlphabetNameNode); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence); try { derSequence.IndexOfNonGap(); Assert.Fail("The method is now implemented"); } catch (NotImplementedException) { Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of IndexOfNonGap() method of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of IndexOfNonGap() method of derived sequence completed successfully"); } }
public void ValidateDnaDerivedSequenceGetSubSequence() { // Get input and expected values from xml string expectedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.AlphabetNameNode); string rangeObj = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.Range); string expSubSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.RangeSequence); string derivedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.DerivedSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence); string[] ranges = rangeObj.Split(','); // Validate IndexOf() derived Sequence. Assert.AreEqual(derivedSequence, new string(derSequence.Select(a => (char)a).ToArray())); Assert.AreEqual(expSubSequence, new string(derSequence.GetSubSequence(long.Parse(ranges[0], (IFormatProvider)null), long.Parse(ranges[1], (IFormatProvider)null)).Select(a => (char)a).ToArray())); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetSubSequence() method of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetSubSequence() method of derived sequence completed successfully"); }
public void InValidateReplaceDerivedSequenceItems() { // Pass protein sequences ISequence seqObj = new Sequence(Alphabets.DNA, "AAGGTT"); DerivedSequence deriSeqObj = new DerivedSequence(seqObj); // Pass invalid index value and get the exception required try { deriSeqObj.Replace(-1, deriSeqObj[0]); Assert.Fail(); } catch (ArgumentException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for ReplaceRange() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for ReplaceRange() method"); } // Pass invalid sequence and get the exception required try { deriSeqObj.Replace(1, null); Assert.Fail(); } catch (ArgumentNullException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for ReplaceRange() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for ReplaceRange() method"); } }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Validates expected items are present in derived sequence using Contains() method. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceContains(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.DerivedSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence, addSequence, removeRange); // Validate Contains() derived Sequence. Assert.AreEqual(derivedSequence, derSequence.ToString()); Sequence sequence = new Sequence(alphabet, addSequence); foreach (ISequenceItem item in sequence) { Assert.IsTrue(derSequence.Contains(item)); } Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Contains() method of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Contains() method of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Clear the derived sequence changes and validated that it matches against oroginal sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceClear(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence, addSequence, removeRange); // clear the changes. derSequence.Clear(); // Validate derived Sequence changes are cleared // It matches now with source sequence. Assert.AreEqual(expectedSequence, derSequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Clear() method of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Clear() method of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after removing few items using RemoveAt() from original sequence. /// Validates it against expected sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceRemoveAt(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange1); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveDerivedSequence2); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence. Sequence seq = new Sequence(alphabet, expectedSequence); DerivedSequence derSequence = new DerivedSequence(seq); string[] removals = removeRange.Split(','); int position = int.Parse(removals[0], null); int length = int.Parse(removals[1], null); // Remove items for (int index = position; index <= length; index++) { derSequence.RemoveAt(index); } // Validate Derived Sequence Assert.AreEqual(derivedSequence, derSequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of RemoveAt() of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of RemoveAt() of derived sequence completed successfully"); }
public void ValidateCopyTo() { // Get input and expected values from xml string expectedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.AlphabetNameNode); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence seqObj = CreateDerivedSequence( alphabet, expectedSequence); byte[] array = new byte[expectedSequence.Length]; seqObj.CopyTo(array, 0, expectedSequence.Length); StringBuilder builder = new StringBuilder(); for (int i = 0; i < expectedSequence.Length; i++) { builder.Append((char)array[i]); } string actualValue = builder.ToString(); Assert.AreEqual(expectedSequence, actualValue); //check with a part of the expected seq only seqObj.CopyTo(array, 0, 5); builder = new StringBuilder(); for (int i = 0; i < 5; i++) { builder.Append((char)array[i]); } actualValue = builder.ToString(); Assert.AreEqual(expectedSequence.Substring(0, 5), actualValue); }
/// <summary> /// Creates a dna derived sequence after inserting few items using Insert(pos,item) from original sequence. /// Validates it against expected sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceInsertWithSequenceItem(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.InsertDerivedSequence); string insertSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence. Sequence seq = new Sequence(alphabet, expectedSequence); DerivedSequence derSequence = new DerivedSequence(seq); int position = 1; // Insert sequence item Sequence insertSeq = new Sequence(alphabet, insertSequence); foreach (ISequenceItem item in insertSeq) { derSequence.Insert(position, item); } // Validate Derived Sequence Assert.AreEqual(derivedSequence, derSequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Insert() by passing item of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Insert() by passing item of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding few items using Add() from original sequence. /// Validates it against expected sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceAdd(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddDerivedSequence); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence. Sequence seq = new Sequence(alphabet, expectedSequence); DerivedSequence derSequence = new DerivedSequence(seq); // Add sequence item Sequence addSeq = new Sequence(alphabet, addSequence); foreach (ISequenceItem item in addSeq) { derSequence.Add(item); } // Validate Derived Sequence Assert.AreEqual(derivedSequence, derSequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Add() of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Add() of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Create a copy of derived sequence and validates it against expected sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceClone(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.DerivedSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence, addSequence, removeRange); DerivedSequence derSequenceCopy = derSequence.Clone(); // Validate copy of derived Sequence. Assert.AreEqual(derSequence.ToString(), derSequenceCopy.ToString()); Assert.AreEqual(derivedSequence, derSequenceCopy.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Clone() of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Clone() of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Replace few items by passing char using Replace() and validates it against expected sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceReplaceWithChar(string nodeName) { // Get input and expected values from xml string expectedSequence = Utility._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = Utility._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string derivedSequence = Utility._xmlUtil.GetTextValue( nodeName, Constants.ReplaceSequence); string replaceSequence = Utility._xmlUtil.GetTextValue( nodeName, Constants.ReplaceRangeSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence. Sequence seq = new Sequence(alphabet, expectedSequence); DerivedSequence derSequence = new DerivedSequence(seq); int position = 0; // Replace sequence with char. Sequence replaceSeq = new Sequence(alphabet, replaceSequence); foreach (ISequenceItem item in replaceSeq) { derSequence.Replace(position, item.Symbol); position++; } // Validate Derived Sequence Assert.AreEqual(derivedSequence, derSequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Replace() by passing char of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Replace() by passing char of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Get a sub sequence using Range() and validates it against expected sequence. /// </summary> /// <param name="nodeName"></param> private void ValidateDerivedSequenceRange(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); string rangeSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RangeSequence); string range = _utilityObj._xmlUtil.GetTextValue(nodeName, Constants.Range); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence, addSequence, removeRange); string[] ranges = range.Split(','); int position = int.Parse(ranges[0], null); int length = int.Parse(ranges[1], null); ISequence sequence = derSequence.Range(position, length); // Validate range Sequence. Assert.AreEqual(rangeSequence, sequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of Range() of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of Range() of derived sequence completed successfully"); }
public void ValidateDnaDerivedSequenceGetComplemented() { // Get input and expected values from xml string expectedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.AlphabetNameNode); string complementObj = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.Complement); string derivedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.DerivedSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence); // Validate IndexOf() derived Sequence. Assert.AreEqual(derivedSequence, new string(derSequence.Select(a => (char)a).ToArray())); Assert.AreEqual(complementObj, new string(derSequence.GetComplementedSequence().Select(a => (char)a).ToArray())); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetComplementedSequence() method of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetComplementedSequence() method of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Validates items of derived sequence using GeEnumerator() /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceGetEnumerator(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.DerivedSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence, addSequence, removeRange); // Validate GetEnumerator() derived Sequence. Assert.AreEqual(derivedSequence, derSequence.ToString()); IEnumerator <ISequenceItem> list = derSequence.GetEnumerator(); int index = 0; while (list.MoveNext()) { Assert.AreEqual(list.Current.Symbol, derivedSequence[index]); index++; } Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetEnumerator() method of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetEnumerator() method of derived sequence completed successfully"); }
public void ValidateDnaDerivedSequenceProperties() { // Get input and expected values from xml string expectedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.AlphabetNameNode); string derivedSequence = utilityObj.xmlUtil.GetTextValue( Constants.DnaDerivedSequenceNode, Constants.DerivedSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence); // Validate properties of derived Sequence. Assert.AreEqual(derivedSequence, new string(derSequence.Select(a => (char)a).ToArray())); Assert.AreEqual(alphabet, derSequence.Alphabet); Assert.IsNotNull(derSequence.Metadata); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of properties of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of properties of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Replace few items using ReplaceRange() and validates it against expected sequence. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceReplaceRange(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ReplaceSequence); string replaceSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ReplaceRangeSequence); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence. Sequence seq = new Sequence(alphabet, expectedSequence); DerivedSequence derSequence = new DerivedSequence(seq); int position = 0; // Replace range of sequence. derSequence.ReplaceRange(position, replaceSequence); // Validate Derived Sequence Assert.AreEqual(derivedSequence, derSequence.ToString()); Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of ReplaceRange() of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of ReplaceRange() of derived sequence completed successfully"); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// </summary> /// <param name="alphabet">Alphabet</param> /// <param name="source">source sequence</param> private static DerivedSequence CreateDerivedSequence( IAlphabet alphabet, string source) { ISequence seq = new Sequence(alphabet, source); DerivedSequence derSequence = new DerivedSequence(seq, false, false); return(derSequence); }
public void TestDerivedSequenceConvertToString() { Sequence baseSeq = new Sequence(Alphabets.DNA, "ATCGATCGGATCGATCGGCTACTAATATCGATCGGCTACGATCGGCTAATCGATCGATCGGCTAATCGATCGATCGGCTAGCTA"); DerivedSequence seq = new DerivedSequence(baseSeq, false, false); const string expectedValue = "TCGATCGGCT"; string actualValue = seq.ConvertToString(10, 10); Assert.AreEqual(expectedValue, actualValue); }
public void TestGetReverseComplementedSequence() { const string sequence = "ATGCC"; const string expectedSequence = "GGCAT"; ISequence orignalSequence = new Sequence(Alphabets.DNA, sequence); DerivedSequence deriveSequence = new DerivedSequence(orignalSequence, false, false); string actualSequence = new string(deriveSequence.GetReverseComplementedSequence().Select(a => (char)a).ToArray()); Assert.AreEqual(expectedSequence, actualSequence); }
public void TestDerivedSequenceConvertToString() { Sequence baseSeq = new Sequence(Alphabets.DNA, "ATCGATCGGATCGATCGGCTACTAATATCGATCGGCTACGATCGGCTAATCGATCGATCGGCTAATCGATCGATCGGCTAGCTA"); DerivedSequence seq = new DerivedSequence(baseSeq, false, false); const string expectedValue = "TCGATCGGCT"; string actualValue = seq.ConvertToString(10, 10); Assert.AreEqual(expectedValue, actualValue); }
public void TestGetReverseComplementedSequence() { const string sequence = "ATGCC"; const string expectedSequence = "GGCAT"; ISequence orignalSequence = new Sequence(Alphabets.DNA, sequence); DerivedSequence deriveSequence = new DerivedSequence(orignalSequence, false, false); string actualSequence = new string(deriveSequence.GetReverseComplementedSequence().Select(a => (char)a).ToArray()); Assert.AreEqual(expectedSequence, actualSequence); }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// Validates its updated items against expected updated items. /// </summary> /// <param name="nodeName">alphabet xml node.</param> private void ValidateDerivedSequenceGetUpdatedItems(string nodeName) { // Get input and expected values from xml string expectedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.ExpectedSequence); string alphabetName = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AlphabetNameNode); string removeRange = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.RemoveRange); string addSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.AddSequence); string derivedSequence = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.DerivedSequence); string updatedItems = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.UpdatedItemList); string updatedIndices = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.UpdatedItemsIndex); string updatedTypes = _utilityObj._xmlUtil.GetTextValue( nodeName, Constants.UpdatedTypeList); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence DerivedSequence derSequence = CreateDerivedSequence( alphabet, expectedSequence, addSequence, removeRange); string[] updatedIndexList = updatedIndices.Split(','); string[] updatedTypesList = updatedTypes.Split(','); Assert.AreEqual(updatedTypesList.Length, updatedIndexList.Length); // Validate derived Sequence. Assert.AreEqual(derivedSequence, derSequence.ToString()); // Validate GetUpdatedItems IList <IndexedItem <UpdatedSequenceItem> > actualUpdatedItemList = derSequence.GetUpdatedItems(); Assert.AreEqual(updatedIndexList.Length, actualUpdatedItemList.Count); for (int index = 0; index < actualUpdatedItemList.Count; index++) { Assert.AreEqual(updatedIndexList[index], actualUpdatedItemList[index].Index.ToString((IFormatProvider)null)); Assert.AreEqual(updatedItems[index].ToString(), actualUpdatedItemList[index].Item.SequenceItem.Symbol.ToString((IFormatProvider)null)); Assert.AreEqual(updatedTypesList[index], actualUpdatedItemList[index].Item.Type.ToString()); } Console.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetUpdatedItems() of derived sequence completed successfully"); ApplicationLog.WriteLine( "DerivedSequenceBvtTestCases:Validation of GetUpdatedItems() of derived sequence completed successfully"); }
public void TestDeriveSequenceCopyTo() { ISequence seq = new Sequence(Alphabets.DNA, "ATCG"); DerivedSequence derSeq = new DerivedSequence(seq, false, true); byte[] array = new byte[2]; derSeq.CopyTo(array, 1, 2); string expectedValue = "AG"; StringBuilder b = new StringBuilder(); b.Append((char)array[0]); b.Append((char)array[1]); string actualValue = b.ToString(); Assert.AreEqual(expectedValue, actualValue); }
public void ValidateDerivedContainsNullSeqItem() { // Pass protein sequences ISequence seqObj = new Sequence(Alphabets.Protein, "EEE"); DerivedSequence deriSeq = new DerivedSequence(seqObj); // Validate null sequence item in the derived sequence object Assert.IsFalse(deriSeq.Contains(null)); ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the Contains method for null sequence item"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the Contains method for null sequence item"); }
public void ValidateDerivedIndexOfNull() { Sequence seqObj = new Sequence(Alphabets.Protein, "KIE"); // Valid index of validation DerivedSequence deriSeq = new DerivedSequence(seqObj); Assert.AreEqual(-1, deriSeq.IndexOf(null)); ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated IndexOf() method with null values"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the IndexOf() method with null values"); }
public void ValidateDerivedInvalidRemove() { // Pass protein sequences ISequence seqObj = new Sequence(Alphabets.DNA, "AAGGTT"); DerivedSequence deriSeqObj = new DerivedSequence(seqObj); ISequence tempSeq = new Sequence(Alphabets.DNA, "C"); Assert.IsFalse(deriSeqObj.Remove(tempSeq[0])); ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveAt() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveAt() method"); }
public void TestDerivedSequenceToString() { ISequence seqSmall = new Sequence(Alphabets.DNA, "ATCG"); ISequence seqLarge = new Sequence(Alphabets.DNA, "ATCGGGGGGGGGGGGGGGGGGGGGGGGCCCCCCCCCCCCCCCCCCCCCCGGGGGGGGGGTTTTTTTTTTTTTTT"); ISequence DeriveSeqSmall = new DerivedSequence(seqSmall, false, true); ISequence DeriveSeqLarge = new DerivedSequence(seqLarge, false, true); string ActualSmallString = DeriveSeqSmall.ToString(); string ActualLargeString = DeriveSeqLarge.ToString(); string ExpectedSmallString = "TAGC"; string expectedLargeString = string.Format(CultureInfo.CurrentCulture, "TAGCCCCCCCCCCCCCCCCCCCCCCCCGGGGGGGGGGGGGGGGGGGGGGCCCCCCCCCCAAAAA... +[{0}]", (seqLarge.Count - Helper.AlphabetsToShowInToString)); Assert.AreEqual(ExpectedSmallString, ActualSmallString); Assert.AreEqual(expectedLargeString, ActualLargeString); }
public void ValidateDerivedSeqInvalidRange() { // Pass protein sequences ISequence seqObj = new Sequence(Alphabets.DNA, "AAGGTT"); DerivedSequence deriSeqObj = new DerivedSequence(seqObj); // Pass invalid index value and get the exception required try { deriSeqObj.Range(-1, -1); Assert.IsTrue(false); } catch (ArgumentOutOfRangeException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for Range() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for Range() method"); } // Pass length value lesser than zero. try { deriSeqObj.Range(1, -21); Assert.IsTrue(false); } catch (ArgumentOutOfRangeException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for Range() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for Range() method"); } // Pass invalid length and startPos value. try { deriSeqObj.Range(2, 6); Assert.IsTrue(false); } catch (ArgumentException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for Range() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for Range() method"); } }
public void ValidateDerivedInvalidRemoveRange() { // Pass protein sequences ISequence seqObj = new Sequence(Alphabets.DNA, "AAGGTT"); DerivedSequence deriSeqObj = new DerivedSequence(seqObj); // Pass invalid index value and get the exception required try { deriSeqObj.RemoveRange(-1, 0); Assert.Fail(); } catch (ArgumentOutOfRangeException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveRange() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveRange() method"); } // Pass invalid length value and get the exception required try { deriSeqObj.RemoveRange(3, -1); Assert.Fail(); } catch (ArgumentException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveRange() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveRange() method"); } // Pass invalid length, index value and get the exception required try { deriSeqObj.RemoveRange(1, 10); Assert.Fail(); } catch (ArgumentException) { ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveRange() method"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the exception for RemoveRange() method"); } }
public void ValidateDerivedContainsDnaRnaSeqItem() { // Pass protein sequences ISequence seqObj = new Sequence(Alphabets.DNA, "GCT"); ISequence tempObj = new Sequence(Alphabets.RNA, "UUU"); ISequenceItem seqItemObj = tempObj[0]; DerivedSequence deriSeq = new DerivedSequence(seqObj); // Validate in valid sequence item in the derived sequence object Assert.IsFalse(deriSeq.Contains(seqItemObj)); ApplicationLog.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the Contains method for Rna sequence item"); Console.WriteLine( "DerivedSequenceP2TestCases : Successfully validated the Contains method for Rna sequence item"); }
public void TestDeriveSequenceCopyTo() { ISequence seq = new Sequence(Alphabets.DNA, "ATCG"); DerivedSequence derSeq = new DerivedSequence(seq, false, true); byte[] array = new byte[2]; derSeq.CopyTo(array, 1, 2); string expectedValue = "AG"; StringBuilder b = new StringBuilder(); b.Append((char)array[0]); b.Append((char)array[1]); string actualValue = b.ToString(); Assert.AreEqual(expectedValue, actualValue); }
public void ValidateDerivedSequenceToString() { ISequence seqSmall = new Sequence(Alphabets.DNA, "ATCG"); string seqLargeStr = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeStringNode); ISequence seqLarge = new Sequence(Alphabets.DNA, seqLargeStr); ISequence DeriveSeqSmall = new DerivedSequence(seqSmall, false, true); ISequence DeriveSeqLarge = new DerivedSequence(seqLarge, false, true); string ActualSmallString = DeriveSeqSmall.ToString(); string ActualLargeString = DeriveSeqLarge.ToString(); string ExpectedSmallString = "TAGC"; string seqLargeExpected = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeExpectedNode); string expectedLargeString = string.Format(CultureInfo.CurrentCulture, seqLargeExpected, (seqLarge.Count - Helper.AlphabetsToShowInToString)); Assert.AreEqual(ExpectedSmallString, ActualSmallString); Assert.AreEqual(expectedLargeString, ActualLargeString); //read sequences from file // Get input and expected values from xml string expectedSequence = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.AlphabetNameNode); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence ISequence seq = new Sequence(alphabet, expectedSequence); var derSequence = new DerivedSequence(seq, false, false); string actualDerivedSeqStr = derSequence.ToString(); if (actualDerivedSeqStr.Length > Helper.AlphabetsToShowInToString) { //check if the whole sequence string contains the string retrieved from ToString Assert.IsTrue( expectedSequence.Contains(derSequence.ToString().Substring(0, Helper.AlphabetsToShowInToString))); Assert.IsTrue(derSequence.ToString().Contains("... +[")); } else { Assert.AreEqual(expectedSequence, derSequence.ToString()); } }
public void ValidateDerivedSequenceConvertToString() { string seqLargeStr = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeStringNode); ISequence seqLarge = new Sequence(Alphabets.DNA, seqLargeStr); ISequence DeriveSeqLarge = new DerivedSequence(seqLarge, false, true); string ActualLargeString = DeriveSeqLarge.ToString(); string seqLargeExpected = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeExpectedNode); string expectedLargeString = string.Format(CultureInfo.CurrentCulture, seqLargeExpected, (seqLarge.Count - Helper.AlphabetsToShowInToString)); Assert.AreEqual(expectedLargeString, ActualLargeString); // Get input and expected values from xml string expectedSequence = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.AlphabetNameNode); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence ISequence seq = new Sequence(alphabet, expectedSequence); var derSequence = new DerivedSequence(seq, false, false); Assert.AreEqual(expectedSequence.Substring(2, 5), derSequence.ConvertToString(2, 5)); }
public void InvalidateDerivedSequenceConvertToString() { try { //check with blank sequene var baseSeq = new Sequence(Alphabets.DNA, ""); var seq = new DerivedSequence(baseSeq, false, false); string seqStr = seq.ConvertToString(0, 3); Assert.Fail(); } catch (ArgumentOutOfRangeException aorex) { ApplicationLog.WriteLine("Successfully caught ArgumentOutOfRangeException : " + aorex.Message); } try { //check with length greater than actual length var baseSeq = new Sequence(Alphabets.DNA, "ATGCCCC"); var seq = new DerivedSequence(baseSeq, false, false); string seqStr = seq.ConvertToString(0, 30); Assert.Fail(); } catch (ArgumentOutOfRangeException aorex) { ApplicationLog.WriteLine("Successfully caught ArgumentOutOfRangeException : " + aorex.Message); } try { //check with length < 0 var baseSeq = new Sequence(Alphabets.DNA, "ATGCCCC"); var seq = new DerivedSequence(baseSeq, false, false); string seqStr = seq.ConvertToString(0, -30); Assert.Fail(); } catch (ArgumentOutOfRangeException aorex) { ApplicationLog.WriteLine("Successfully caught ArgumentOutOfRangeException : " + aorex.Message); } try { //check with start index < 0 var baseSeq = new Sequence(Alphabets.DNA, "ATGCCCC"); var seq = new DerivedSequence(baseSeq, false, false); string seqStr = seq.ConvertToString(-10, 3); Assert.Fail(); } catch (ArgumentOutOfRangeException aorex) { ApplicationLog.WriteLine("Successfully caught ArgumentOutOfRangeException : " + aorex.Message); } try { //check with start index greater than actual length var baseSeq = new Sequence(Alphabets.DNA, "ATGCCCC"); var seq = new DerivedSequence(baseSeq, false, false); string seqStr = seq.ConvertToString(30, 3); Assert.Fail(); } catch (ArgumentOutOfRangeException aorex) { ApplicationLog.WriteLine("Successfully caught ArgumentOutOfRangeException : " + aorex.Message); } try { //check with null sequence Sequence baseSeq = null; var seq = new DerivedSequence(baseSeq, false, false); string seqStr = seq.ConvertToString(0, 3); Assert.Fail(); } catch (NullReferenceException nre) { ApplicationLog.WriteLine("Successfully caught ArgumentOutOfRangeException : " + nre.Message); } }
public void ValidateDerivedSequenceToString() { ISequence seqSmall = new Sequence(Alphabets.DNA, "ATCG"); string seqLargeStr = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeStringNode); ISequence seqLarge = new Sequence(Alphabets.DNA, seqLargeStr); ISequence DeriveSeqSmall = new DerivedSequence(seqSmall, false, true); ISequence DeriveSeqLarge = new DerivedSequence(seqLarge, false, true); string ActualSmallString = DeriveSeqSmall.ToString(); string ActualLargeString = DeriveSeqLarge.ToString(); string ExpectedSmallString = "TAGC"; string seqLargeExpected = this.utilityObj.xmlUtil.GetTextValue(Constants.ToStringNodeName, Constants.seqLargeExpectedNode); string expectedLargeString = string.Format(CultureInfo.CurrentCulture, seqLargeExpected, (seqLarge.Count - Helper.AlphabetsToShowInToString)); Assert.AreEqual(ExpectedSmallString, ActualSmallString); Assert.AreEqual(expectedLargeString, ActualLargeString); //read sequences from file // Get input and expected values from xml string expectedSequence = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.ExpectedSequence); string alphabetName = this.utilityObj.xmlUtil.GetTextValue( Constants.ProteinDerivedSequenceNode, Constants.AlphabetNameNode); IAlphabet alphabet = Utility.GetAlphabet(alphabetName); // Create derived Sequence ISequence seq = new Sequence(alphabet, expectedSequence); var derSequence = new DerivedSequence(seq, false, false); string actualDerivedSeqStr = derSequence.ToString(); if (actualDerivedSeqStr.Length > Helper.AlphabetsToShowInToString) { //check if the whole sequence string contains the string retrieved from ToString Assert.IsTrue( expectedSequence.Contains(derSequence.ToString().Substring(0, Helper.AlphabetsToShowInToString))); Assert.IsTrue(derSequence.ToString().Contains("... +[")); } else { Assert.AreEqual(expectedSequence, derSequence.ToString()); } }
/// <summary> /// Creates a dna derived sequence after adding and removing few items from original sequence. /// </summary> /// <param name="alphabet">Alphabet</param> /// <param name="source">source sequence</param> private static DerivedSequence CreateDerivedSequence( IAlphabet alphabet, string source) { ISequence seq = new Sequence(alphabet, source); DerivedSequence derSequence = new DerivedSequence(seq, false, false); return derSequence; }
public void TestDerivedSequenceToString() { ISequence seqSmall = new Sequence(Alphabets.DNA, "ATCG"); ISequence seqLarge = new Sequence(Alphabets.DNA, "ATCGGGGGGGGGGGGGGGGGGGGGGGGCCCCCCCCCCCCCCCCCCCCCCGGGGGGGGGGTTTTTTTTTTTTTTT"); ISequence DeriveSeqSmall = new DerivedSequence(seqSmall, false, true); ISequence DeriveSeqLarge = new DerivedSequence(seqLarge, false, true); string ActualSmallString = DeriveSeqSmall.ToString(); string ActualLargeString = DeriveSeqLarge.ToString(); string ExpectedSmallString = "TAGC"; string expectedLargeString = string.Format(CultureInfo.CurrentCulture, "TAGCCCCCCCCCCCCCCCCCCCCCCCCGGGGGGGGGGGGGGGGGGGGGGCCCCCCCCCCAAAAA... +[{0}]", (seqLarge.Count - Helper.AlphabetsToShowInToString)); Assert.AreEqual(ExpectedSmallString, ActualSmallString); Assert.AreEqual(expectedLargeString, ActualLargeString); }
/// <summary> /// Returns a sequence which contains bases from the specified sequence as specified by the location. /// If the location contains accession then the sequence from the referredSequences which matches the /// accession of the location will be considered. /// /// For example, /// if location is "join(100..200, J00089.1:10..50, J00090.2:30..40)" /// then bases from 100 to 200 will be considered from the sequence parameter and referredSequences will /// be searched for the J00089.1 and J00090.2 accession if found then those sequences will be considered /// for constructing the output sequence. /// If the referred sequence is not found in the referredSequences then an exception will occur. /// </summary> /// <param name="location">Location instance.</param> /// <param name="sequence">Sequence instance from which the sub sequence has to be returned.</param> /// <param name="referredSequences">A dictionary containing Accession numbers as keys and Sequences as values, this will be used when /// the location or sub-locations contains accession.</param> public ISequence GetSubSequence(ILocation location, ISequence sequence, Dictionary<string, ISequence> referredSequences) { if (location == null) { throw new ArgumentNullException(Properties.Resource.ParameterNameLocation); } if (sequence == null) { throw new ArgumentNullException(Properties.Resource.ParameterNameSequence); } DerivedSequence basicDerSeq; if (location.Operator == LocationOperator.Complement) { if (location.SubLocations.Count > 1) { throw new ArgumentException(Properties.Resource.ComplementWithMorethanOneSubLocs); } if (location.SubLocations.Count > 0) { basicDerSeq = new DerivedSequence(location.SubLocations[0].GetSubSequence(sequence, referredSequences), false, true); } else { basicDerSeq = new DerivedSequence(GetSubSequence(location.LocationStart, location.LocationEnd, location.Accession, location.Separator, sequence, referredSequences), false, true); } byte[] tempSeqData = new byte[basicDerSeq.Count]; for (int i = 0; i < basicDerSeq.Count; i++) { tempSeqData[i] = basicDerSeq[i]; } return new Sequence(sequence.Alphabet, tempSeqData); } if (location.Operator == LocationOperator.Order) { List<ISequence> subSequences = new List<ISequence>(); if (location.SubLocations.Count > 0) { foreach (ILocation loc in location.SubLocations) { subSequences.Add(loc.GetSubSequence(sequence, referredSequences)); } } else { basicDerSeq = new DerivedSequence(GetSubSequence(location.LocationStart, location.LocationEnd, location.Accession, location.Separator, sequence, referredSequences), false, false); byte[] seqData = new byte[basicDerSeq.Count]; for (long i = 0; i < basicDerSeq.Count; i++) { seqData[i] = basicDerSeq[i]; } subSequences.Add(new Sequence(sequence.Alphabet, seqData)); } long totalSubSequenceLength = 0; long j = 0; foreach (ISequence seq in subSequences) { totalSubSequenceLength += seq.Count; } byte[] tempSeqData = new byte[totalSubSequenceLength]; totalSubSequenceLength = 0; IAlphabet alphabet = null; int m = 0; foreach (ISequence seq in subSequences) { totalSubSequenceLength += seq.Count; while (j < totalSubSequenceLength) { tempSeqData[j] = seq[m]; j++; m++; } m = 0; alphabet = seq.Alphabet; } //return Segmented sequence. return new Sequence(alphabet, tempSeqData); } if (location.Operator == LocationOperator.Join || location.Operator == LocationOperator.Bond) { if (location.SubLocations.Count > 0) { List<ISequence> subSequences = new List<ISequence>(); foreach (ILocation loc in location.SubLocations) { subSequences.Add(loc.GetSubSequence(sequence, referredSequences)); } long i = 0; long subSeqLength = 0; foreach (ISequence subSeq in subSequences) { subSeqLength += subSeq.Count; } byte[] seqData = new byte[subSeqLength]; subSeqLength = 0; int m = 0; foreach (ISequence subSeq in subSequences) { subSeqLength += subSeq.Count; while (i < subSeqLength) { seqData[i] = subSeq[m]; i++; m++; } m = 0; } Sequence seq = new Sequence(sequence.Alphabet,seqData); return seq; } else { return GetSubSequence(location.LocationStart, location.LocationEnd, location.Accession, location.Separator, sequence, referredSequences); } } if (location.SubLocations.Count > 0) { throw new ArgumentException(Properties.Resource.NoneWithSubLocs); } return GetSubSequence(location.LocationStart, location.LocationEnd, location.Accession, location.Separator, sequence, referredSequences); }