public override void ToXml(XElement document)
{
HER2AnalysisSummaryTestOrder panelSetOrder = (HER2AnalysisSummaryTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddCompanyHeader(document);
this.AddBlankNteElement(document);
this.AddNextNteElement("HER2 Analysis Summary", document);
this.AddNextNteElement("Master Accession #: " + panelSetOrder.MasterAccessionNo, document);
this.AddNextNteElement("Report #: " + panelSetOrder.ReportNo, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Result", document);
string result = panelSetOrder.Result;
if (result == null)
{
result = string.Empty;
}
if (result.ToUpper() == "NEGATIVE")
{
result += " (see interpretation)";
}
this.AddNextNteElement("HER2 Status: " + result, document);
if (panelSetOrder.Her2Chr17Ratio.HasValue == true)
{
this.AddNextNteElement("HER2 by ISH", document);
this.AddNextNteElement("HER2/Chr17 Ratio = " + panelSetOrder.AverageHer2Chr17Signal, document);
}
if (panelSetOrder.AverageHer2NeuSignal.HasValue == true)
{
this.AddNextNteElement("Average HER2 Copy Number = " + panelSetOrder.AverageHer2NeuSignal.Value.ToString(), document);
}
this.AddNextNteElement("Cells Counted:" + panelSetOrder.CellsCounted.ToString(), document);
this.AddNextNteElement("HER2 Signals Counted:" + panelSetOrder.TotalHer2SignalsCounted.ToString(), document);
this.AddNextNteElement("Chr17 Signals Counted:" + panelSetOrder.TotalChr17SignalsCounted.ToString(), document);
this.AddBlankNteElement(document);
this.AddNextNteElement("HER2 by IHC:" + panelSetOrder.IHCScore, document);
this.AddBlankNteElement(document);
if (panelSetOrder.RecountRequired == true)
{
this.AddNextNteElement("HER2 By ISH Recount", document);
this.AddNextNteElement("Cells Counted: " + panelSetOrder.CellsRecount.ToString(), document);
this.AddNextNteElement("HER2 Signals Counted: " + panelSetOrder.TotalHer2SignalsRecount.ToString(), document);
this.AddNextNteElement("Chr17 Signals Counted: " + panelSetOrder.TotalChr17SignalsRecount.ToString(), document);
this.AddBlankNteElement(document);
}
if (string.IsNullOrEmpty(panelSetOrder.ResultComment) == false)
{
this.HandleLongString("Comment: " + panelSetOrder.ResultComment, document);
this.AddBlankNteElement(document);
}
this.AddNextNteElement("Pathologist: " + panelSetOrder.Signature, document);
if (panelSetOrder.FinalDate.HasValue == true)
{
this.AddNextNteElement("E-signed " + panelSetOrder.FinalDate.Value.ToString("MM/dd/yyyy HH:mm"), document);
}
this.AddBlankNteElement(document);
this.AddAmendments(document, panelSetOrder, this.m_AccessionOrder);
this.AddBlankNteElement(document);
this.AddNextNteElement("Result Data", document);
this.AddNextNteElement("Number of invasive tumor cells counted: " + panelSetOrder.CellsCounted.ToString(), document);
this.AddNextNteElement("Number of observers: " + panelSetOrder.NumberOfObservers, document);
if (panelSetOrder.AverageHer2NeuSignal.HasValue == true)
{
this.AddNextNteElement("HER2 average copy number per nucleus: " + panelSetOrder.AverageHer2NeuSignal.Value.ToString(), document);
}
else
{
this.AddNextNteElement("HER2 average copy number per nucleus: Unable to calculate", document);
}
this.AddNextNteElement("Chr17 average copy number per nucleus: " + panelSetOrder.AverageChr17Signal, document);
if (panelSetOrder.Her2Chr17Ratio.HasValue == true)
{
this.AddNextNteElement("Ratio of average HER2 / Chr17 signals: " + panelSetOrder.Her2Chr17Ratio.Value.ToString(), document);
}
else
{
this.AddNextNteElement("Ratio of average HER2 / Chr17 signals: Unable to calculate", document);
}
this.AddBlankNteElement(document);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrder.OrderedOn, panelSetOrder.OrderedOnId);
YellowstonePathology.Business.Test.AliquotOrder aliquotOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetAliquotOrder(panelSetOrder.OrderedOnId);
string blockDescription = string.Empty;
if (aliquotOrder != null)
{
blockDescription = " - Block " + aliquotOrder.Label;
}
string collectionDateTimeString = YellowstonePathology.Business.Helper.DateTimeExtensions.CombineDateAndTime(specimenOrder.CollectionDate, specimenOrder.CollectionTime);
this.AddNextNteElement("Specimen Information", document);
this.AddNextNteElement("Specimen site and type: " + specimenOrder.Description + blockDescription, document);
this.AddNextNteElement("Specimen fixation type: " + specimenOrder.LabFixation, document);
this.AddNextNteElement("Time to fixation: " + specimenOrder.TimeToFixationHourString, document);
this.AddNextNteElement("Duration of fixation: " + specimenOrder.FixationDurationString, document);
this.AddNextNteElement("Sample adequacy: " + panelSetOrder.SampleAdequacy, document);
this.AddNextNteElement("Collection Date / Time: " + collectionDateTimeString, document);
this.AddBlankNteElement(document);
if (string.IsNullOrEmpty(specimenOrder.FixationComment) == false)
{
this.AddNextNteElement("Fixation Comment:", document);
this.HandleLongString(specimenOrder.FixationComment, document);
this.AddBlankNteElement(document);
}
if (panelSetOrder.InterpretiveComment != null)
{
this.AddNextNteElement("Interpretation:", document);
this.HandleLongString(panelSetOrder.InterpretiveComment, document);
this.AddBlankNteElement(document);
}
this.AddNextNteElement("Reference Ranges:", document);
this.AddNextNteElement("Positive", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH ≥2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH ≥4.0", document);
this.AddNextNteElement("HER2 Result by IHC N/A", document);
this.AddNextNteElement("or", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH ≥2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH <4.0", document);
this.AddNextNteElement("HER2 Result by IHC 3+", document);
this.AddNextNteElement("or", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH <2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH ≥4.0 but <6.0", document);
this.AddNextNteElement("HER2 Result by IHC 3+", document);
this.AddNextNteElement("or", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH <2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH ≥6.0", document);
this.AddNextNteElement("HER2 Result by IHC 2+ or 3+", document);
this.AddNextNteElement("Negative", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH <2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH <4.0", document);
this.AddNextNteElement("HER2 Result by IHC N/A", document);
this.AddNextNteElement("or", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH ≥2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH <4.0", document);
this.AddNextNteElement(" HER2 Result by IHC 0, 1+, or 2+", document);
this.AddNextNteElement("or", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH <2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH ≥4.0 but <6.0", document);
this.AddNextNteElement("HER2 Result by IHC 0, 1+, or 2+", document);
this.AddNextNteElement("or", document);
this.AddNextNteElement("HER2/ Chr17 Ratio by ISH <2.0", document);
this.AddNextNteElement("Average HER2 Copy Number Per Cell by ISH ≥6.0", document);
this.AddNextNteElement("HER2 Result by IHC 0 or 1+", document);
this.AddBlankNteElement(document);
this.AddNextNteElement("References: ", document);
this.HandleLongString(panelSetOrder.ReportReference, document);
this.AddBlankNteElement(document);
this.AddNextNteElement(panelSetOrder.ASRComment, document);
this.AddBlankNteElement(document);
string locationPerformed = panelSetOrder.GetLocationPerformedComment();
this.AddNextNteElement(locationPerformed, document);
this.AddBlankNteElement(document);
}
public override void Render()
{
HER2AnalysisSummaryTestOrder her2AmplificationSummaryTestOrder = (HER2AnalysisSummaryTestOrder)this.m_PanelSetOrder;
if (her2AmplificationSummaryTestOrder.Indicator.ToUpper() == "BREAST")
{
if (this.m_AccessionOrder.AccessionDate >= DateTime.Parse("1/1/2014") == true)
{
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\Her2AmplificationSummary.Breast.xml";
}
else
{
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\HER2AmplificationByISH.ASCOPre2014.1.xml";
}
}
else if (her2AmplificationSummaryTestOrder.Indicator.ToUpper() == "GASTRIC")
{
if (this.m_AccessionOrder.AccessionDate >= DateTime.Parse("1/1/2014") == true)
{
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\Her2AmplificationByISH.Gastric.2.xml";
}
else
{
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\HER2AmplificationByISH.ASCOPre2014.1.xml";
}
}
base.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
this.SetCaseHistory();
if (this.m_AccessionOrder.OrderCancelled == false)
{
YellowstonePathology.Business.Amendment.Model.AmendmentCollection amendmentCollection = this.m_AccessionOrder.AmendmentCollection.GetAmendmentsForReport(m_PanelSetOrder.ReportNo);
YellowstonePathology.Business.Document.AmendmentSection amendmentSection = new YellowstonePathology.Business.Document.AmendmentSection();
amendmentSection.SetAmendment(amendmentCollection, this.m_ReportXml, this.m_NameSpaceManager, true);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(this.m_PanelSetOrder.OrderedOn, this.m_PanelSetOrder.OrderedOnId);
string collectionDateTimeString = YellowstonePathology.Business.Helper.DateTimeExtensions.CombineDateAndTime(specimenOrder.CollectionDate, specimenOrder.CollectionTime);
this.SetXmlNodeData("date_time_collected", collectionDateTimeString);
string result = her2AmplificationSummaryTestOrder.Result;
if (result == null)
{
result = string.Empty;
}
if (result.ToUpper() == "NEGATIVE")
{
result += " (see interpretation)";
}
this.SetXmlNodeData("test_result", result);
this.SetXmlNodeData("ihc_score", her2AmplificationSummaryTestOrder.IHCScore);
//removed per MSB by SEH
//this.SetXmlNodeData("ish_cells_counted", her2AmplificationSummaryTestOrder.CellsCounted.ToString());
//this.SetXmlNodeData("ish_her2_counted", her2AmplificationSummaryTestOrder.TotalHer2SignalsCounted.ToString());
//this.SetXmlNodeData("ish_chr17_counted", her2AmplificationSummaryTestOrder.TotalChr17SignalsCounted.ToString());
if (her2AmplificationSummaryTestOrder.RecountRequired == true)
{
this.SetXmlNodeData("re_cells_counted", her2AmplificationSummaryTestOrder.CellsRecount.ToString());
this.SetXmlNodeData("re_her2_counted", her2AmplificationSummaryTestOrder.TotalHer2SignalsRecount.ToString());
this.SetXmlNodeData("re_chr17_counted", her2AmplificationSummaryTestOrder.TotalChr17SignalsRecount.ToString());
}
else
{
this.DeleteRow("HER2 By ISH Recount");
this.DeleteRow("re_cells_counted");
this.DeleteRow("re_her2_counted");
this.DeleteRow("re_chr17_counted");
}
if (her2AmplificationSummaryTestOrder.Her2Chr17Ratio.HasValue == true)
{
this.SetXmlNodeData("test_ratio", "HER2/Chr17 Ratio = " + her2AmplificationSummaryTestOrder.AverageHer2Chr17Signal);
}
else
{
this.DeleteRow("test_ratio");
}
if (her2AmplificationSummaryTestOrder.AverageHer2NeuSignal.HasValue == true)
{
this.SetXmlNodeData("copy_number", "Average HER2 Copy Number = " + her2AmplificationSummaryTestOrder.AverageHer2NeuSignal.Value.ToString());
}
else
{
this.DeleteRow("copy_number");
}
this.SetXmlNodeData("cell_cnt", her2AmplificationSummaryTestOrder.CellsCounted.ToString());
if (her2AmplificationSummaryTestOrder.AverageHer2NeuSignal.HasValue == true)
{
this.SetXmlNodeData("avg_her", her2AmplificationSummaryTestOrder.AverageHer2NeuSignal.Value.ToString());
}
else
{
this.SetXmlNodeData("avg_her", "Unable to calculate");
}
this.SetXmlNodeData("avg_chr", her2AmplificationSummaryTestOrder.AverageChr17Signal);
if (her2AmplificationSummaryTestOrder.Her2Chr17Ratio.HasValue == true)
{
this.SetXmlNodeData("tst_ratio", her2AmplificationSummaryTestOrder.Her2Chr17Ratio.Value.ToString());
}
else
{
this.SetXmlNodeData("tst_ratio", "Unable to calculate");
}
this.SetXmlNodeData("obs_cnt", her2AmplificationSummaryTestOrder.NumberOfObservers.ToString());
this.SetXmlNodeData("final_date", YellowstonePathology.Business.BaseData.GetShortDateString(this.m_PanelSetOrder.FinalDate));
if (string.IsNullOrEmpty(her2AmplificationSummaryTestOrder.ResultComment) == false)
{
this.SetXmlNodeData("result_comment", her2AmplificationSummaryTestOrder.ResultComment);
this.SetXmlNodeData("comment_up", string.Empty);
}
else
{
this.DeleteRow("result_comment");
this.DeleteRow("comment_up");
}
XmlNode tableNode = this.m_ReportXml.SelectSingleNode("descendant::w:tbl[w:tr/w:tc/w:p/w:r/w:t='report_interpretation']", this.m_NameSpaceManager);
if (her2AmplificationSummaryTestOrder.InterpretiveComment != null)
{
this.SetXMLNodeParagraphDataNode(tableNode, "report_interpretation", her2AmplificationSummaryTestOrder.InterpretiveComment);
}
else
{
this.SetXMLNodeParagraphDataNode(tableNode, "report_interpretation", string.Empty);
}
YellowstonePathology.Business.Test.AliquotOrder aliquotOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetAliquotOrder(this.m_PanelSetOrder.OrderedOnId);
string blockDescription = string.Empty;
if (aliquotOrder != null)
{
blockDescription = " - Block " + aliquotOrder.Label;
}
SetXmlNodeData("specimen_type", specimenOrder.Description + blockDescription);
SetXmlNodeData("specimen_fixation", specimenOrder.LabFixation);
SetXmlNodeData("time_to_fixation", specimenOrder.TimeToFixationHourString);
this.SetXmlNodeData("report_reference", her2AmplificationSummaryTestOrder.ReportReference);
SetXmlNodeData("duration_of_fixation", specimenOrder.FixationDurationString);
if (string.IsNullOrEmpty(specimenOrder.FixationComment) == false)
{
this.SetXmlNodeData("fixation_comment", specimenOrder.FixationComment);
}
else
{
this.SetXmlNodeData("fixation_comment", string.Empty);
}
SetXmlNodeData("report_method", her2AmplificationSummaryTestOrder.Method);
SetXmlNodeData("asr_comment", her2AmplificationSummaryTestOrder.ASRComment);
SetXmlNodeData("sample_adequacy", her2AmplificationSummaryTestOrder.SampleAdequacy);
SetXmlNodeData("date_time_collected", collectionDateTimeString);
SetXmlNodeData("report_distribution", "No Distribution Selected");
this.SetXmlNodeData("pathologist_signature", this.m_PanelSetOrder.Signature);
}
else
{
this.SetXmlNodeData("result_comment", her2AmplificationSummaryTestOrder.ResultComment);
this.SetXmlNodeData("final_date", YellowstonePathology.Business.BaseData.GetShortDateString(this.m_PanelSetOrder.FinalDate));
}
this.SaveReport();
}