Beispiel #1
0
        public static Testcase Read(string patientID)
        {
            Testcase testCase = new Testcase();

            // Read subject.csv to get the patient data
            // Read icustay.csv to get the stays
            // Read the events files to get the events
            return(testCase);
        }
Beispiel #2
0
        private void ReadButton_Click(object sender, EventArgs e)
        {
            string patientID = PatientIdTextBox.Text;

            if (patientID != "")
            {
                Testcase testCase = Testcase.Read(patientID);
            }
        }
        // Create a testcase for hypokalemia from a generic MIMIC III testcase
        TestcaseHypokalemia(Testcase testcase)
        {
            // Find the first prescription for a potassium suplement
            DateTime treatmentTimestamp = DateTime.UtcNow;

            // Store the first prescription as the expected result for analysis
            // Find the inputs for the hypokalemia algorithm

            // GFR (ml/min)
            // Get the age
            double age = testcase.age(treatmentTimestamp);

            if (age >= 0)
            {
                GenericEvent firstCreatinineEvent  = testcase.GetLatestLabEvent(new string[] { "creatinine" }, treatmentTimestamp);
                GenericEvent secondCreatinineEvent = null;
                if (firstCreatinineEvent != null)
                {
                    double GFR1 = GFR(firstCreatinineEvent.valueNum, age, testcase.ethnicity, testcase.gender);
                    if (GFR1 > 0.0)
                    {
                        testData.SetValue("gfr", GFR1, "mL/min/1.73 m2", firstCreatinineEvent.chartDateTime);
                        double GFR2 = -1;
                        secondCreatinineEvent = testcase.GetLatestLabEvent(new string[] { "creatinine" }, firstCreatinineEvent.chartDateTime);
                        if (secondCreatinineEvent != null)
                        {
                            GFR2 = GFR(secondCreatinineEvent.valueNum, age, testcase.ethnicity, testcase.gender);
                            if (GFR2 >= 0.0)
                            {
                                testData.SetValue("gfr", GFR2, "mL/min/1.73 m2", secondCreatinineEvent.chartDateTime);
                            }
                        }
                    }
                }
                else
                {
                    results.actions.Add(new AutoICU.AI.Action("Creatinine missing."));
                    results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Creatinine is required to calculate the estimated GFR."));
                    return;
                }
            }
            else
            {
                results.actions.Add(new AutoICU.AI.Action("Age missing."));
                results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Age is required to calculate the estimated GFR."));
                return;
            }

            // Urine Production (ml/kg/hr)
            // Get the last weight
            GenericEvent weightEvent = testcase.GetLatestEvent(new string[] { "weight" }, treatmentTimestamp);

            if (weightEvent != null)
            {
                double weight = weightEvent.valueNum;

                DateTime     previousDate    = treatmentTimestamp.AddDays(-1);
                DateTime     firstTimestamp  = treatmentTimestamp;
                DateTime     lastTimestamp   = firstTimestamp;
                double       urineProduction = -1;
                GenericEvent genericEvent    = testcase.GetLatestOutputEvent(new string[] { "foley" }, firstTimestamp);
                while (genericEvent != null && genericEvent.valueNum >= 0 && genericEvent.chartDateTime >= previousDate)
                {
                    firstTimestamp = genericEvent.chartDateTime;
                    if (urineProduction < 0.0)
                    {
                        lastTimestamp   = firstTimestamp;
                        urineProduction = 0.0;
                    }
                    urineProduction += genericEvent.valueNum;
                    genericEvent     = testcase.GetLatestOutputEvent(new string[] { "foley" }, firstTimestamp);
                }
                if (firstTimestamp != lastTimestamp)
                {
                    urineProduction -= genericEvent.valueNum;
                    urineProduction  = urineProduction / (lastTimestamp - firstTimestamp).Minutes / 60 / weight;
                    testData.SetValue("urine production", urineProduction, "ml/kg/hr", lastTimestamp);
                }
            }
            else
            {
                results.actions.Add(new AutoICU.AI.Action("Weight missing."));
                results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Weight is required to calculate the Urine Production."));
                return;
            }

            // Potassium (mEq/l)
            GenericEvent labEvent = testcase.GetLatestLabEvent(new string[] { "potassium" }, treatmentTimestamp);

            if (labEvent != null)
            {
                testData.SetValue("potassium", labEvent.valueNum, "mEq/l", labEvent.chartDateTime);
            }
            else
            {
                results.actions.Add(new AutoICU.AI.Action("Potassium missing."));
                results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Potassium is required to determine the recommended treatment."));
                return;
            }

            //values.Add(new ValueSet("Magnesium (mg/dl)"));
            labEvent = testcase.GetLatestLabEvent(new string[] { "magnesium" }, treatmentTimestamp);
            if (labEvent != null)
            {
                testData.SetValue("magnesium", labEvent.valueNum, "mg/dl", labEvent.chartDateTime);
            }

            //values.Add(new ValueSet("Phosphorus (mg/dl)"));
            labEvent = testcase.GetLatestLabEvent(new string[] { "phosphorus" }, treatmentTimestamp);
            if (labEvent != null)
            {
                testData.SetValue("phosphorus", labEvent.valueNum, "mg/dl", labEvent.chartDateTime);
            }

            //values.Add(new ValueSet("Calcium, Ionized (mg/dl)"));
            labEvent = testcase.GetLatestLabEvent(new string[] { "calcium, ionized" }, treatmentTimestamp);
            if (labEvent != null)
            {
                testData.SetValue("calcium, ionized", labEvent.valueNum, "mg/dl", labEvent.chartDateTime);
            }
            else
            {
                labEvent = testcase.GetLatestLabEvent(new string[] { "calcium, total" }, treatmentTimestamp);
                if (labEvent != null)
                {
                    double totalCalcium = labEvent.valueNum;
                    labEvent = testcase.GetLatestLabEvent(new string[] { "albumin" }, treatmentTimestamp);
                    if (labEvent != null)
                    {
                        testData.SetValue("calcium, corrected", totalCalcium + 0.8 * (4.0 - Math.Min(4.0, labEvent.valueNum)),
                                          "mg/dl", labEvent.chartDateTime);
                    }
                }
            }

            //values.Add(new ValueSet("Diarrhea (Y/N)"));
            labEvent = testcase.GetLatestLabEvent(new string[] { "diarrhea" }, treatmentTimestamp);
            if (labEvent != null)
            {
                testData.SetValue("diarrhea", "Y", "", treatmentTimestamp);
            }
            else
            {
                testData.SetValue("diarrhea", "N", "", treatmentTimestamp);
            }

            //treatments.Add(new ValueSet("KCL (mEq)"));
            DateTime            earliestTreatmentDate = treatmentTimestamp.AddDays(-2);
            DateTime            latestTimestamp       = treatmentTimestamp;
            List <GenericEvent> prescriptionEvents    = testcase.GetLatestPrescriptionEvents(hypokalemiaTreatments, earliestTreatmentDate, treatmentTimestamp);

            foreach (GenericEvent prescriptionEvent in prescriptionEvents)
            {
                testData.SetValue("kcl", prescriptionEvent.valueNum, prescriptionEvent.valueUnits, prescriptionEvent.chartDateTime);
            }
        }