NGlycanHybrid CreateByAddFucCore()
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[2] = 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.Fuc);
return(g);
}
NGlycanHybrid CreateByAddGlcNAcBisect()
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[3] = 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.GlcNAc);
return(g);
}
NGlycanHybrid CreateByAddManCore()
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[1] = g.table_[1] + 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.Man);
glycans.Add(g);
return(g);
}
List <NGlycanHybrid> CreateByAddManBranch()
{
List <NGlycanHybrid> glycans = new List <NGlycanHybrid>();
for (int i = 0; i < 2; i++)
{
if (i == 0 || table_[i + 4] < table_[i + 3]) // make it order
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[i + 4] = g.table_[i + 4] + 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.Man);
glycans.Add(g);
}
}
return(glycans);
}
List <NGlycanHybrid> CreateByAddNeuGc()
{
List <NGlycanHybrid> glycans = new List <NGlycanHybrid>();
for (int i = 0; i < 2; i++)
{
if (i == 0 || table_[i + 14] < table_[i + 13]) // make it order
{
if (table_[i + 6] > 0 && table_[i + 6] == table_[i + 8] && table_[i + 12] == 0 && table_[i + 14] == 0)
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[i + 14] = 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.NeuGc);
glycans.Add(g);
}
}
}
return(glycans);
}
List <NGlycanHybrid> CreateByAddFucTerminal()
{
List <NGlycanHybrid> glycans = new List <NGlycanHybrid>();
for (int i = 0; i < 2; i++)
{
if (i == 0 || table_[i + 10] < table_[i + 9]) // make it order
{
if (table_[i + 10] == 0 && table_[i + 6] > 0)
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[i + 10] = 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.Fuc);
glycans.Add(g);
}
}
}
return(glycans);
}
List <NGlycanHybrid> CreateByAddGal()
{
List <NGlycanHybrid> glycans = new List <NGlycanHybrid>();
for (int i = 0; i < 2; i++)
{
if (i == 0 || table_[i + 8] < table_[i + 7]) // make it order
{
if (table_[i + 6] == table_[i + 8] + 1)
{
var g = new NGlycanHybrid();
g.SetTable(table_);
g.table_[i + 8] = g.table_[i + 8] + 1;
g.SetComposition(composite);
g.AddMonosaccharide(Monosaccharide.Gal);
glycans.Add(g);
}
}
}
return(glycans);
}
public override List <IGlycan> Grow(Monosaccharide monosaccharide)
{
List <IGlycan> glycans = new List <IGlycan>();
switch (monosaccharide)
{
case Monosaccharide.GlcNAc:
if (ValidAddGlcNAcCore())
{
NGlycanHybrid ptr = CreateByAddGlcNAcCore();
glycans.Add(ptr);
}
else if (ValidAddGlcNAc())
{
if (ValidAddGlcNAcBisect())
{
NGlycanHybrid ptr = CreateByAddGlcNAcBisect();
glycans.Add(ptr);
}
if (ValidAddGlcNAcBranch())
{
List <NGlycanHybrid> gs = CreateByAddGlcNAcBranch();
glycans.AddRange(gs);
}
}
break;
case Monosaccharide.Man:
if (ValidAddManCore())
{
NGlycanHybrid ptr = CreateByAddManCore();
glycans.Add(ptr);
}
else if (ValidAddManBranch())
{
List <NGlycanHybrid> gs = CreateByAddManBranch();
glycans.AddRange(gs);
}
break;
case Monosaccharide.Gal:
if (ValidAddGal())
{
List <NGlycanHybrid> gs = CreateByAddGal();
glycans.AddRange(gs);
}
break;
case Monosaccharide.Fuc:
if (ValidAddFucCore())
{
NGlycanHybrid ptr = CreateByAddFucCore();
glycans.Add(ptr);
}
if (ValidAddFucTerminal())
{
List <NGlycanHybrid> gs = CreateByAddFucTerminal();
glycans.AddRange(gs);
}
break;
case Monosaccharide.NeuAc:
if (ValidAddNeuAc())
{
List <NGlycanHybrid> gs = CreateByAddNeuAc();
glycans.AddRange(gs);
}
break;
case Monosaccharide.NeuGc:
if (ValidAddNeuGc())
{
List <NGlycanHybrid> gs = CreateByAddNeuGc();
glycans.AddRange(gs);
}
break;
default:
break;
}
return(glycans);
}
