public static List <string> GetAutoCompleteData(string prefixText, int count)
{
const int minPrefixLength = 3;
List <string> valuesList = new List <string>();
if (prefixText.Length >= minPrefixLength)
{
try
{
List <Drug_Information> drugs = EF_Data.GetDrugsQuery(prefixText);
foreach (Drug_Information drug in drugs)
{
valuesList.Add(drug.Other_Drug_Name_Alias);
valuesList.Add(drug.Drug_Common_Name);
valuesList.Add(drug.Drug_Chemical_Name);
valuesList.Add(drug.Compound_CAS_ID);
valuesList.Add(drug.PubChem_CID);
valuesList.Add(drug.ChEMBL_ID);
}
}
catch (Exception)
{
throw;
}
}
return(DataUtilities.FilterDropdownList(valuesList, prefixText));
}
/// <summary>
/// Author: Andy Tang
/// </summary>
protected void Search_Textbox_Changed(object sender, EventArgs e)
{
search_drop_down.Items.Clear();
search_drop_down.Items.Add(DROP_DOWN_PROMPT_MESSAGE);
List <Protein_Information> proteinList = new List <Protein_Information>();
const int minPrefixLength = 3;
if (search_textBox.Text.Length < minPrefixLength)
{
return;
}
Drug_Information drug = EF_Data.GetDrugsQuery(search_textBox.Text).FirstOrDefault();
if (drug != null)
{
List <PDB_Information> pdbInfoList = EF_Data.GetPDBInfoUsingDrug(drug.Drug_PDB_ID);
foreach (PDB_Information pdb in pdbInfoList)
{
Protein_Information protein = EF_Data.GetProteinByUniprotID(pdb.UniProt_ID);
if (protein != null)
{
proteinList.Add(protein);
}
}
}
if (proteinList.Count > 0)
{
List <string> valuesList = new List <string>();
foreach (Protein_Information protein in proteinList)
{
valuesList.Add(protein.UniProt_ID);
valuesList.Add(protein.Protein_Short_Name);
valuesList.Add(protein.Protein_Full_Name);
valuesList.Add(protein.Protein_Alias);
valuesList.Add(protein.NCBI_RefSeq_NP_ID);
valuesList.Add(protein.PhosphoNET_Name);
valuesList.Add(protein.PDB_Protein_Name);
}
valuesList = DataUtilities.FilterDropdownList(valuesList);
foreach (string value in valuesList)
{
search_drop_down.Items.Add(new ListItem(value, value, true));
}
}
else
{
search_drop_down.Items.Clear();
search_drop_down.Items.Add(DROP_DOWN_NO_MATCHES_MESSAGE);
}
}
/// <summary>
/// Author: Andy Tang, Ryan Liang
/// </summary>
protected new void Page_Load(object sender, EventArgs e)
{
base.Page_Load(sender, e);
if (!IsPostBack)
{
string fromPage = null;
string query_string = null;
try
{
query_string = Request.QueryString["query_string"];
drug_specification = Request.QueryString["drug_specification"];
protein_specification = Request.QueryString["protein_specification"];
if (!string.IsNullOrEmpty(drug_specification))
{
protein_specification = query_string;
fromPage = "protein";
}
else if (!string.IsNullOrEmpty(protein_specification))
{
drug_specification = query_string;
fromPage = "drug";
}
drug = EF_Data.GetDrugsQuery(drug_specification).FirstOrDefault();
protein = EF_Data.GetProteinsInfoQuery(protein_specification).FirstOrDefault();
PDB = EF_Data.GetPDBInfo(protein, drug);
Session["PDB_File_ID"] = PDB.PDB_File_ID;
interaction_distance = double.Parse(Request.QueryString["interaction_distance"]);
protein_chain = bool.Parse(Request.QueryString["protein_chain"]);
protein_atoms = bool.Parse(Request.QueryString["protein_atoms"]);
protein_residues = bool.Parse(Request.QueryString["protein_residues"]);
protein_residue_numbers = bool.Parse(Request.QueryString["protein_residue_numbers"]);
drug_atoms = bool.Parse(Request.QueryString["drug_atoms"]);
Session["interaction_distance"] = interaction_distance;
}
catch (Exception)
{
throw;
}
if (drug == null || protein == null || PDB == null)
{
Page.Master.FindControl("BodyContentPlaceHolder").Visible = false;
if (fromPage != null)
{
ExceptionUtilities.DisplayAlert(this, fromPage.Equals("drug") ? DRUG_QUERY_PAGE : PROTEIN_QUERY_PAGE);
}
else
{
ExceptionUtilities.DisplayAlert(this, DEFAULT_REDIRECT_PAGE);
}
}
else
{
Session["interaction_distance"] = interaction_distance;
Session["protein_chain"] = protein_chain;
Session["protein_atoms"] = protein_atoms;
Session["protein_residues"] = protein_residues;
Session["protein_residue_numbers"] = protein_residue_numbers;
Session["drug_atoms"] = drug_atoms;
LoadProtein(protein);
LoadDrug(drug, PDB);
LoadPDB_Info(PDB);
GetDrugAtomNumberingImage(drug);
CreateInteractionList(PDB, interaction_distance, protein_chain, protein_atoms, protein_residues, protein_residue_numbers, drug_atoms);
CreateInteractionSummary();
ScriptManager.RegisterStartupScript(Page, GetType(), "D_3DViewer", "javascript:loadDrugLigand('" + drug.Drug_PDB_ID + "');", true);
ScriptManager.RegisterStartupScript(Page, GetType(), "PDB_3DViewer", "javascript:loadStage('" + drug.PDB_File_ID + "', '" + drug.Drug_PDB_ID + "');", true);
}
}
}
