Beispiel #1
0
        /// <summary>
        /// parses the relevant data from each variant effect feature cache
        /// </summary>
        public static void ParseReference(ObjectValue objectValue, DataStructures.VEP.VariantEffectFeatureCache cache, ImportDataStore dataStore)
        {
            // loop over all of the key/value pairs in the cache object
            foreach (AbstractData ad in objectValue)
            {
                switch (ad.Key)
                {
                case IntronsKey:
                    var intronsList = ad as ListObjectKeyValue;
                    if (intronsList != null)
                    {
                        Intron.ParseListReference(intronsList.Values, cache.Introns, dataStore);
                    }
                    break;

                case MapperKey:
                    var mapperNode = ad as ObjectKeyValue;
                    if (mapperNode != null)
                    {
                        TranscriptMapper.ParseReference(mapperNode.Value, cache.Mapper, dataStore);
                    }
                    break;

                case ProteinFunctionPredictionsKey:
                    var predictionsNode = ad as ObjectKeyValue;
                    if (predictionsNode != null)
                    {
                        ProteinFunctionPredictions.ParseReference(predictionsNode.Value, cache.ProteinFunctionPredictions, dataStore);
                    }
                    break;
                }
            }
        }
Beispiel #2
0
        /// <summary>
        /// parses the relevant data from each variant effect feature cache
        /// </summary>
        public static DataStructures.VEP.VariantEffectFeatureCache Parse(ObjectValue objectValue, ImportDataStore dataStore)
        {
            var cache = new DataStructures.VEP.VariantEffectFeatureCache();

            // loop over all of the key/value pairs in the cache object
            foreach (AbstractData ad in objectValue)
            {
                // sanity check: make sure we know about the keys are used for
                if (!KnownKeys.Contains(ad.Key))
                {
                    throw new GeneralException(
                              $"Encountered an unknown key in the dumper variant effect feature cache object: {ad.Key}");
                }

                // handle each key
                switch (ad.Key)
                {
                case SelenocysteinesKey:
                case ThreePrimeUtrKey:
                case SeqEditsKey:
                case CodonTableKey:
                case ProteinFeaturesKey:
                    // not used
                    break;

                case IntronsKey:
                    var intronsList = ad as ListObjectKeyValue;
                    if (intronsList != null)
                    {
                        cache.Introns = Intron.ParseList(intronsList.Values, dataStore);
                    }
                    else if (DumperUtilities.IsUndefined(ad))
                    {
                        cache.Introns = null;
                    }
                    else
                    {
                        throw new GeneralException(
                                  $"Could not transform the AbstractData object into a ListObjectKeyValue: [{ad.GetType()}]");
                    }
                    break;

                case MapperKey:
                    var mapperNode = ad as ObjectKeyValue;
                    if (mapperNode != null)
                    {
                        cache.Mapper = TranscriptMapper.Parse(mapperNode.Value, dataStore);
                    }
                    else
                    {
                        throw new GeneralException(
                                  $"Could not transform the AbstractData object into an ObjectKeyValue: [{ad.GetType()}]");
                    }
                    break;

                case PeptideKey:
                    cache.Peptide = DumperUtilities.GetString(ad);
                    break;

                case ProteinFunctionPredictionsKey:
                    var predictionsNode = ad as ObjectKeyValue;
                    if (predictionsNode != null)
                    {
                        cache.ProteinFunctionPredictions = ProteinFunctionPredictions.Parse(predictionsNode.Value);
                    }
                    else
                    {
                        throw new GeneralException(
                                  $"Could not transform the AbstractData object into an ObjectKeyValue: [{ad.GetType()}]");
                    }

                    break;

                case SortedExonsKey:
                    var exonsList = ad as ListObjectKeyValue;
                    if (exonsList != null)
                    {
                        cache.Exons = Exon.ParseList(exonsList.Values, dataStore);
                    }
                    else
                    {
                        throw new GeneralException($"Could not transform the AbstractData object into a ListObjectKeyValue: [{ad.GetType()}]");
                    }
                    break;

                case TranslateableSeqKey:
                    cache.TranslateableSeq = DumperUtilities.GetString(ad);
                    break;

                default:
                    throw new GeneralException($"Unknown key found: {ad.Key}");
                }
            }

            return(cache);
        }