protected override void Context()
        {
            base.Context();
            _key1 = "key1";
            _key2 = "key2";
            _key3 = "key3";
            _key4 = "key4";

            var loadedProtocol1 = A.Fake <Protocol>().WithName("P1");

            loadedProtocol1.IsLoaded = true;
            A.CallTo(() => loadedProtocol1.UsedFormulationKeys).Returns(new[] { _key1, _key2 });
            var notLoadedProtocol = A.Fake <Protocol>().WithName("P2");

            A.CallTo(() => notLoadedProtocol.UsedFormulationKeys).Returns(new[] { "tralala" });

            var loadedProtocol2 = A.Fake <Protocol>().WithName("P3");

            loadedProtocol2.IsLoaded = true;
            A.CallTo(() => loadedProtocol2.UsedFormulationKeys).Returns(new[] { _key2, _key3 });

            var project = new PKSimProject();

            project.AddBuildingBlock(loadedProtocol1);
            project.AddBuildingBlock(loadedProtocol2);
            project.AddBuildingBlock(notLoadedProtocol);

            var formulation = new Formulation().WithName(_key4);

            project.AddBuildingBlock(formulation);
            A.CallTo(() => _projectRetriever.CurrentProject).Returns(project);
        }
Beispiel #2
0
        protected override void Context()
        {
            _project          = new PKSimProject();
            _projectRetriever = A.Fake <IPKSimProjectRetriever>();
            A.CallTo(() => _projectRetriever.Current).Returns(_project);

            _compound1          = A.Fake <Compound>();
            _compound1.IsLoaded = false;
            _compound2          = new Compound {
                IsLoaded = true
            };
            _compound2.AddProcess(new EnzymaticProcess {
                MoleculeName = "A", Name = "P1"
            });
            _compound2.AddProcess(new EnzymaticProcess {
                MoleculeName = "C", Name = "P2"
            });
            _compound2.AddProcess(new EnzymaticProcess {
                MoleculeName = "B", Name = "P3"
            });

            _individual1          = A.Fake <Individual>();
            _individual1.IsLoaded = false;
            _individual2          = new Individual {
                IsLoaded = true
            };
            _individual2.AddMolecule(new IndividualEnzyme().WithName("B"));
            _individual2.AddMolecule(new IndividualEnzyme().WithName("D"));

            _project.AddBuildingBlock(_compound1);
            _project.AddBuildingBlock(_compound2);
            _project.AddBuildingBlock(_individual1);
            _project.AddBuildingBlock(_individual2);
            sut = new UsedMoleculeRepository(_projectRetriever);
        }
Beispiel #3
0
        protected override async Task Context()
        {
            await base.Context();

            _snapshot = await sut.MapToSnapshot(_individual);

            _project = new PKSimProject();

            _snapshotContext = new SnapshotContext(_project, ProjectVersions.V11);

            _snapshot.Name        = "New individual";
            _snapshot.Description = "The description that will be deserialized";

            //clear enzyme before mapping them again
            _individual.RemoveExpressionProfile(_expressionProfile1);
            _individual.RemoveExpressionProfile(_expressionProfile2);

            //reset parameter
            _parameterKidney.ResetToDefault();

            _project.AddBuildingBlock(_expressionProfile1);
            _project.AddBuildingBlock(_expressionProfile2);

            _newOriginData = new Model.OriginData();
            A.CallTo(() => _originDataMapper.MapToModel(_snapshot.OriginData, A <SnapshotContext> ._)).Returns(_newOriginData);

            A.CallTo(() => _individualFactory.CreateAndOptimizeFor(_newOriginData, _snapshot.Seed))
            .Returns(_individual);
        }
        protected override Task Context()
        {
            _individualSimulationComparisonMapper = A.Fake <IndividualSimulationComparisonMapper>();
            _populationAnalysisChartMapper        = A.Fake <PopulationAnalysisChartMapper>();
            _objectBaseFactory = A.Fake <IObjectBaseFactory>();
            sut = new SimulationComparisonMapper(_individualSimulationComparisonMapper, _populationAnalysisChartMapper, _objectBaseFactory);

            _individualSimulation1 = new IndividualSimulation().WithName("IndS1").WithId("IndS1");
            _individualSimulation2 = new IndividualSimulation().WithName("IndS2").WithId("IndS2");

            _individualSimulationComparison = new IndividualSimulationComparison
            {
                Name        = "IndividualComparison",
                Description = "IndividualComparison Description",
            };

            _individualSimulationComparison.AddSimulation(_individualSimulation1);
            _individualSimulationComparison.AddSimulation(_individualSimulation2);


            _populationSimulation1 = new PopulationSimulation().WithName("PopS1").WithId("PopS1");
            _populationSimulation2 = new PopulationSimulation().WithName("PopS2").WithId("PopS2");
            _referenceSimulation   = new PopulationSimulation().WithName("PopS3").WithId("PopS3");

            _populationSimulationComparison = new PopulationSimulationComparison
            {
                Name        = "PopulationComparison",
                Description = "PopulationComparison Description",
            };

            _populationSimulationAnalysis = new BoxWhiskerAnalysisChart();
            _populationSimulationComparison.AddSimulation(_populationSimulation1);
            _populationSimulationComparison.AddSimulation(_populationSimulation2);
            _populationSimulationComparison.AddAnalysis(_populationSimulationAnalysis);

            _populationSimulationComparison.ReferenceGroupingItem = new GroupingItem();
            _populationSimulationComparison.ReferenceSimulation   = _referenceSimulation;

            _curveChart = new CurveChart();
            A.CallTo(() => _individualSimulationComparisonMapper.MapToSnapshot(_individualSimulationComparison)).Returns(_curveChart);

            _populationAnalysisChartSnapshot = new Snapshots.PopulationAnalysisChart();
            A.CallTo(() => _populationAnalysisChartMapper.MapToSnapshot(_populationSimulationAnalysis)).Returns(_populationAnalysisChartSnapshot);


            _project = new PKSimProject();
            _project.AddBuildingBlock(_individualSimulation1);
            _project.AddBuildingBlock(_individualSimulation2);
            _project.AddBuildingBlock(_populationSimulation1);
            _project.AddBuildingBlock(_populationSimulation2);
            _project.AddBuildingBlock(_referenceSimulation);

            _snapshotContext = new SnapshotContext(_project, ProjectVersions.V10);
            return(_completed);
        }
        protected override void Context()
        {
            _projectRetriever = A.Fake <IPKSimProjectRetriever>();
            sut = new BuildingBlockRepository(_projectRetriever);

            _project = new PKSimProject();
            A.CallTo(() => _projectRetriever.Current).Returns(_project);

            _individual1 = new Individual().WithName("IND1");
            _individual2 = new Individual().WithName("IND2");
            _project.AddBuildingBlock(_individual1);
            _project.AddBuildingBlock(_individual2);
        }
        public override void GlobalContext()
        {
            base.GlobalContext();
            var moleculeExpressionTask = IoC.Resolve <IMoleculeExpressionTask <Individual> >();

            _templateIndividual = DomainFactoryForSpecs.CreateStandardIndividual();
            _templateExpressionProfileCYP3A4 = DomainFactoryForSpecs.CreateExpressionProfile <IndividualEnzyme>("CYP3A4");
            moleculeExpressionTask.AddExpressionProfile(_templateIndividual, _templateExpressionProfileCYP3A4);

            _templateIndividualUsingSameProfile = DomainFactoryForSpecs.CreateStandardIndividual().WithName("IND2");
            moleculeExpressionTask.AddExpressionProfile(_templateIndividualUsingSameProfile, _templateExpressionProfileCYP3A4);

            _templateIndividualUsingAnotherProfile = DomainFactoryForSpecs.CreateStandardIndividual().WithName("IND3");
            _templateExpressionProfileCYP2D6       = DomainFactoryForSpecs.CreateExpressionProfile <IndividualEnzyme>("CYP2D6");
            moleculeExpressionTask.AddExpressionProfile(_templateIndividualUsingAnotherProfile, _templateExpressionProfileCYP2D6);

            var compound = DomainFactoryForSpecs.CreateStandardCompound();
            var protocol = DomainFactoryForSpecs.CreateStandardIVBolusProtocol();

            _simulation = DomainFactoryForSpecs.CreateSimulationWith(_templateIndividual, compound, protocol) as IndividualSimulation;

            var project = new PKSimProject();

            project.AddBuildingBlock(compound);
            project.AddBuildingBlock(protocol);
            project.AddBuildingBlock(_simulation);
            project.AddBuildingBlock(_templateIndividual);
            project.AddBuildingBlock(_templateIndividualUsingSameProfile);
            project.AddBuildingBlock(_templateIndividualUsingAnotherProfile);
            project.AddBuildingBlock(_templateExpressionProfileCYP3A4);
            project.AddBuildingBlock(_templateExpressionProfileCYP2D6);
            var workspace = IoC.Resolve <ICoreWorkspace>();

            workspace.Project = project;
        }
        protected override void Context()
        {
            _project          = new PKSimProject();
            _projectRetriever = A.Fake <IPKSimProjectRetriever>();
            _transporterContainerTemplateRepository = A.Fake <ITransporterContainerTemplateRepository>();
            A.CallTo(() => _projectRetriever.Current).Returns(_project);

            _compound1          = A.Fake <Compound>();
            _compound1.IsLoaded = false;
            _compound2          = new Compound {
                IsLoaded = true
            };
            _compound2.AddProcess(new EnzymaticProcess {
                MoleculeName = "ProjA", Name = "P1"
            });
            _compound2.AddProcess(new EnzymaticProcess {
                MoleculeName = "ProjC", Name = "P2"
            });
            _compound2.AddProcess(new EnzymaticProcess {
                MoleculeName = "ProjB", Name = "P3"
            });


            _ontogenyRepository          = A.Fake <IOntogenyRepository>();
            _moleculeParameterRepository = A.Fake <IMoleculeParameterRepository>();

            _expressionProfile          = A.Fake <ExpressionProfile>();
            _expressionProfile.IsLoaded = true;
            A.CallTo(() => _expressionProfile.MoleculeName).Returns("ProjE");

            _project.AddBuildingBlock(_compound1);
            _project.AddBuildingBlock(_compound2);
            _project.AddBuildingBlock(_expressionProfile);
            sut = new UsedMoleculeRepository(_projectRetriever, _ontogenyRepository, _moleculeParameterRepository, _transporterContainerTemplateRepository);

            var molParam1 = new MoleculeParameter {
                MoleculeName = "DbB"
            };
            var molParam2 = new MoleculeParameter {
                MoleculeName = "DbA"
            };

            A.CallTo(() => _moleculeParameterRepository.All()).Returns(new[] { molParam1, molParam2 });
            A.CallTo(() => _transporterContainerTemplateRepository.AllTransporterNames).Returns(new[] { "ATRANS1", "TRANS2" });

            A.CallTo(() => _ontogenyRepository.AllFor(CoreConstants.Species.HUMAN)).Returns(new[] { new DatabaseOntogeny {
                                                                                                        Name = "OntoC"
                                                                                                    } });
        }
        public IPKSimProject MapFrom(ProjectMetaData projectMetaData)
        {
            var project = new PKSimProject
            {
                Name        = projectMetaData.Name,
                Description = projectMetaData.Description
            };

            //Observed data needs to be loaded first into project
            projectMetaData.AllObservedData.Each(x => project.AddObservedData(mapFrom(x)));

            projectMetaData.BuildingBlocks.Each(x => project.AddBuildingBlock(mapFrom(x)));

            //we need a shared context for all object referencing observed data and simulations
            using (var context = _serializationContextFactory.Create(project.AllObservedData, project.All <ISimulation>()))
            {
                var localContext = context;
                projectMetaData.ParameterIdentifications.Each(x => project.AddParameterIdentification(mapFrom(x, localContext)));
                projectMetaData.SensitivityAnalyses.Each(x => project.AddSensitivityAnalysis(mapFrom(x, localContext)));
            }

            projectMetaData.SimulationComparisons.Each(x => project.AddSimulationComparison(mapFrom(x)));

            //Once reference to dynamic meta data was added, deserialize the project itself
            _serializationManager.Deserialize(project, projectMetaData.Content.Data);

            //if the project DB Version is the same as the current project, the project did not change
            if (projectMetaData.Version == ProjectVersions.Current)
            {
                project.HasChanged = false;
            }

            return(project);
        }
Beispiel #9
0
        public override Task GlobalContext()
        {
            _project                          = new PKSimProject();
            _dialogCreator                    = A.Fake <IDialogCreator>();
            _workspace                        = A.Fake <IWorkspace>();
            _executionContext                 = A.Fake <IExecutionContext>();
            _applicationController            = A.Fake <IApplicationController>();
            _workspaceLayoutUpdater           = A.Fake <IWorkspaceLayoutUpdater>();
            _userSettings                     = A.Fake <IUserSettings>();
            _journalTask                      = A.Fake <IJournalTask>();
            _journalRetriever                 = A.Fake <IJournalRetriever>();
            _snapshotTask                     = A.Fake <ISnapshotTask>();
            _buildingBlockInSimulationManager = A.Fake <IBuildingBlockInSimulationManager>();
            _workspace.Project                = _project;
            _workspace.WorkspaceLayout        = new WorkspaceLayout();
            _heavyWorkManager                 = new HeavyWorkManagerForSpecs();

            _simulation = new IndividualSimulation();

            _project.AddBuildingBlock(_simulation);

            sut = new ProjectTask(_workspace, _applicationController, _dialogCreator,
                                  _executionContext, _heavyWorkManager, _workspaceLayoutUpdater, _userSettings,
                                  _journalTask, _journalRetriever, _snapshotTask, _buildingBlockInSimulationManager);

            _oldFileExitst = FileHelper.FileExists;

            return(_completed);
        }
        protected override Task Context()
        {
            _parameterMapper     = A.Fake <ParameterMapper>();
            _eventMappingFactory = A.Fake <IEventMappingFactory>();
            sut = new EventMappingMapper(_parameterMapper, _eventMappingFactory);

            _event = new PKSimEvent()
                     .WithName("E1")
                     .WithId("EventId");

            _eventMapping = new EventMapping
            {
                TemplateEventId = _event.Id,
                StartTime       = DomainHelperForSpecs.ConstantParameterWithValue(1)
            };

            _snapshotEventStartTime1 = new Parameter {
                Name = "P1"
            };

            _project = new PKSimProject();
            _project.AddBuildingBlock(_event);
            A.CallTo(() => _parameterMapper.MapToSnapshot(_eventMapping.StartTime)).Returns(_snapshotEventStartTime1);

            return(_completed);
        }
Beispiel #11
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        public override void GlobalContext()
        {
            base.GlobalContext();
            _templateIndividual = DomainFactoryForSpecs.CreateStandardIndividual();
            var compound = DomainFactoryForSpecs.CreateStandardCompound();
            var protocol = DomainFactoryForSpecs.CreateStandardIVBolusProtocol();

            _simulation = DomainFactoryForSpecs.CreateSimulationWith(_templateIndividual, compound, protocol) as IndividualSimulation;
            _workspace  = IoC.Resolve <IWorkspace>();
            var project = new PKSimProject();

            project.AddBuildingBlock(compound);
            project.AddBuildingBlock(protocol);
            project.AddBuildingBlock(_simulation);
            project.AddBuildingBlock(_templateIndividual);
            _workspace.Project = project;
        }
Beispiel #12
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        protected override Task Context()
        {
            _parameterIdentificationConfigurationMapper = A.Fake <ParameterIdentificationConfigurationMapper>();
            _outputMappingMapper                   = A.Fake <OutputMappingMapper>();
            _identificationParameterMapper         = A.Fake <IdentificationParameterMapper>();
            _parameterIdentificationAnalysisMapper = A.Fake <ParameterIdentificationAnalysisMapper>();
            _objectBaseFactory = A.Fake <IObjectBaseFactory>();
            _logger            = A.Fake <IOSPSuiteLogger>();

            _project         = new PKSimProject();
            _snapshotContext = new SnapshotContext(_project, ProjectVersions.Current);
            _simulation      = new IndividualSimulation().WithName("S1");
            _project.AddBuildingBlock(_simulation);

            _parameterIdentification = new ModelParameterIdentification();
            _snapshotParameterIndentificationConfiguration = new ParameterIdentificationConfiguration();
            _snapshotOutputMapping = new Snapshots.OutputMapping();
            _outputMapping         = new OutputMapping();
            _parameterIdentification.AddSimulation(_simulation);
            _parameterIdentification.AddOutputMapping(_outputMapping);

            _identificationParameter = new IdentificationParameter {
                Name = "IP"
            };
            _parameterIdentification.AddIdentificationParameter(_identificationParameter);

            _snapshotIdentificationParameter         = new Snapshots.IdentificationParameter();
            _snapshotParameterIdentificationAnalysis = new ParameterIdentificationAnalysis();
            _parameterIdentificationAnalysis         = A.Fake <ISimulationAnalysis>();
            _parameterIdentification.AddAnalysis(_parameterIdentificationAnalysis);


            sut = new ParameterIdentificationMapper(
                _parameterIdentificationConfigurationMapper,
                _outputMappingMapper,
                _identificationParameterMapper,
                _parameterIdentificationAnalysisMapper,
                _objectBaseFactory,
                _logger
                );


            A.CallTo(() => _parameterIdentificationConfigurationMapper.MapToSnapshot(_parameterIdentification.Configuration)).Returns(_snapshotParameterIndentificationConfiguration);
            A.CallTo(() => _outputMappingMapper.MapToSnapshot(_outputMapping)).Returns(_snapshotOutputMapping);
            A.CallTo(() => _identificationParameterMapper.MapToSnapshot(_identificationParameter)).Returns(_snapshotIdentificationParameter);
            A.CallTo(() => _parameterIdentificationAnalysisMapper.MapToSnapshot(_parameterIdentificationAnalysis)).Returns(_snapshotParameterIdentificationAnalysis);

            return(_completed);
        }
        protected override void Context()
        {
            _context       = A.Fake <IExecutionContext>();
            _oldSimulation = new IndividualSimulation().WithName("Old");
            _newSimulation = new IndividualSimulation().WithName("New");
            _project       = new PKSimProject();
            _simulationDifferenceBuilder = A.Fake <ISimulationCommandDescriptionBuilder>();
            _simulationReferenceUpdater  = A.Fake <ISimulationReferenceUpdater>();
            A.CallTo(() => _context.CurrentProject).Returns(_project);
            A.CallTo(() => _context.Resolve <ISimulationCommandDescriptionBuilder>()).Returns(_simulationDifferenceBuilder);
            A.CallTo(() => _context.Resolve <ISimulationReferenceUpdater>()).Returns(_simulationReferenceUpdater);
            var reportPart = new ReportPart();

            reportPart.AddToContent("toto");
            A.CallTo(() => _simulationDifferenceBuilder.BuildDifferenceBetween(_oldSimulation, _newSimulation)).Returns(reportPart);
            sut = new SwapSimulationCommand(_oldSimulation, _newSimulation, _context);

            _project.AddBuildingBlock(_oldSimulation);
        }
Beispiel #14
0
        protected override Task Context()
        {
            _parameterMapper = A.Fake <ParameterMapper>();
            _identificationParameterFactory = A.Fake <IIdentificationParameterFactory>();
            _logger = A.Fake <IOSPSuiteLogger>();
            _identificationParameterTask = A.Fake <IIdentificationParameterTask>();
            sut = new IdentificationParameterMapper(_parameterMapper, _identificationParameterFactory, _identificationParameterTask, _logger);

            _identificationParameter = new IdentificationParameter
            {
                IsFixed     = true,
                UseAsFactor = true,
                Scaling     = Scalings.Linear
            };


            _startValueParameter = DomainHelperForSpecs.ConstantParameterWithValue().WithName(Constants.Parameters.START_VALUE);

            _identificationParameter.Add(_startValueParameter);
            _identificationParameter.Name = "PARAM";
            _parameter1            = DomainHelperForSpecs.ConstantParameterWithValue().WithName("P1");
            _parameter2            = DomainHelperForSpecs.ConstantParameterWithValue().WithName("P2");
            _simulation            = A.Fake <Simulation>().WithName("S");
            _simulation.Model.Root = new Container {
                _parameter1, _parameter2
            };

            _identificationParameter.Scaling = Scalings.Linear;
            _parameterSelection1             = new ParameterSelection(_simulation, _parameter1.Name);
            _parameterSelection2             = new ParameterSelection(_simulation, _parameter2.Name);
            _identificationParameter.AddLinkedParameter(_parameterSelection1);
            _identificationParameter.AddLinkedParameter(_parameterSelection2);

            _snapshotStartValueParameter = new Parameter();
            A.CallTo(() => _parameterMapper.MapToSnapshot(_startValueParameter)).Returns(_snapshotStartValueParameter);

            _project = new PKSimProject();
            _project.AddBuildingBlock(_simulation);
            _snapshotContext                = new SnapshotContext(_project, ProjectVersions.Current);
            _parameterIdentification        = new ParameterIdentification();
            _parameterIdentificationContext = new ParameterIdentificationContext(_parameterIdentification, _snapshotContext);
            return(_completed);
        }
        protected override void Context()
        {
            _executionContext = A.Fake <IExecutionContext>();
            _project          = new PKSimProject();
            A.CallTo(() => _executionContext.CurrentProject).Returns(_project);

            _compound = new Compound().WithId("Tralala").WithName("Tralala");
            _project.AddBuildingBlock(_compound);

            _proc = new EnzymaticProcess().WithName("ActProc1");

            var serializedStream = new byte[1];

            A.CallTo(() => _executionContext.Serialize(_proc)).Returns(serializedStream);
            A.CallTo(() => _executionContext.Deserialize <CompoundProcess>(serializedStream)).Returns(_proc);

            A.CallTo(() => _executionContext.Get <Compound>(_compound.Id)).Returns(_compound);
            A.CallTo(() => _executionContext.Get <CompoundProcess>(_proc.Id)).Returns(_proc);

            sut = new AddProcessToCompoundCommand(_proc, _compound, _executionContext);
        }
        public override void GlobalContext()
        {
            base.GlobalContext();

            _sim1 = new IndividualSimulation
            {
                Id       = "Sim1",
                Name     = "Sim1",
                IsLoaded = true,
                Model    = new Model {
                    Root = new Container()
                }
            };
            _sim1.Model.Root.Add(new Container {
                new Parameter().WithName("P")
            }.WithName("Liver"));

            var objectBaseRepository = IoC.Resolve <IWithIdRepository>();
            var workspace            = IoC.Resolve <IWorkspace>();

            _project          = IoC.Resolve <PKSimProject>();
            workspace.Project = _project;
            objectBaseRepository.Register(_sim1);
            _project.AddBuildingBlock(_sim1);

            _sensitivityAnalysis = new SensitivityAnalysis
            {
                Name       = "SA",
                Simulation = _sim1
            };
            _sensitivityParameter1 = DomainHelperForSpecs.SensitivityParameter(range: 0.5d, steps: 5);
            _parameterSelection1   = new ParameterSelection(_sim1, new QuantitySelection("Liver|P", QuantityType.Parameter));
            _sensitivityParameter1.ParameterSelection = _parameterSelection1;

            _sensitivityAnalysis.AddSensitivityParameter(_sensitivityParameter1);

            _deserializedSensitivityAnalysis = SerializeAndDeserialize(_sensitivityAnalysis);
        }
        public override void GlobalContext()
        {
            base.GlobalContext();
            _observedData = DomainHelperForSpecs.ObservedData();
            _sim1         = new IndividualSimulation
            {
                Id       = "Sim1",
                Name     = "Sim1",
                IsLoaded = true,
                Model    = new Model {
                    Root = new Container()
                }
            };
            _sim1.Model.Root.Add(new Container {
                new Parameter().WithName("P")
            }.WithName("Liver"));
            _sim2 = new IndividualSimulation
            {
                Id       = "Sim2",
                Name     = "Sim2",
                IsLoaded = true,
                Model    = new Model {
                    Root = new Container()
                }
            };
            _sim2.Model.Root.Add(new Container {
                new Parameter().WithName("P")
            }.WithName("Liver"));

            _objectBaseRepository = IoC.Resolve <IWithIdRepository>();
            var workspace = IoC.Resolve <ICoreWorkspace>();

            _project          = IoC.Resolve <PKSimProject>();
            workspace.Project = _project;
            _objectBaseRepository.Register(_sim1);
            _objectBaseRepository.Register(_sim2);
            _project.AddObservedData(_observedData);
            _project.AddBuildingBlock(_sim1);
            _project.AddBuildingBlock(_sim2);

            _parameterIdentification = new ParameterIdentification();
            _parameterIdentification.AddSimulation(_sim1);
            _parameterIdentification.AddSimulation(_sim2);

            _outputMapping = new OutputMapping
            {
                WeightedObservedData = new WeightedObservedData(_observedData),
                OutputSelection      = new SimulationQuantitySelection(_sim1, new QuantitySelection("A|B", QuantityType.Metabolite)),
                Weight  = 5,
                Scaling = Scalings.Log
            };

            _outputMapping.WeightedObservedData.Weights[1] = 10;
            _parameterIdentification.AddOutputMapping(_outputMapping);

            _identificationParameter = DomainHelperForSpecs.IdentificationParameter(min: 1, max: 10, startValue: 5);

            _parameterSelection1 = new ParameterSelection(_sim1, new QuantitySelection("Liver|P", QuantityType.Parameter));
            _parameterSelection2 = new ParameterSelection(_sim2, new QuantitySelection("Liver|P", QuantityType.Parameter));
            _identificationParameter.AddLinkedParameter(_parameterSelection1);
            _identificationParameter.AddLinkedParameter(_parameterSelection2);
            _parameterIdentification.AddIdentificationParameter(_identificationParameter);
            _identificationParameter.Scaling = Scalings.Linear;

            _parameterIdentification.Configuration.AlgorithmProperties = new OptimizationAlgorithmProperties("AA");
            _parameterIdentification.AlgorithmProperties.Add(new ExtendedProperty <double> {
                Name = "Toto", Value = 5
            });

            _runResult = new ParameterIdentificationRunResult();

            _parameterIdentification.AddResult(_runResult);

            _parameterIdentification.AddAnalysis(new ParameterIdentificationPredictedVsObservedChart());
            _parameterIdentification.AddAnalysis(new ParameterIdentificationTimeProfileChart());
            _parameterIdentification.AddAnalysis(new ParameterIdentificationResidualHistogram());
            _parameterIdentification.AddAnalysis(new ParameterIdentificationResidualVsTimeChart());

            GlobalBecause();
        }
Beispiel #18
0
        protected override Task Context()
        {
            _solverSettingsMapper               = A.Fake <SolverSettingsMapper>();
            _outputSchemaMapper                 = A.Fake <OutputSchemaMapper>();
            _outputSelectionMapper              = A.Fake <OutputSelectionsMapper>();
            _parameterMapper                    = A.Fake <ParameterMapper>();
            _compoundPropertiesMapper           = A.Fake <CompoundPropertiesMapper>();
            _advancedParameterMapper            = A.Fake <AdvancedParameterMapper>();
            _eventMappingMapper                 = A.Fake <EventMappingMapper>();
            _observerSetMappingMapper           = A.Fake <ObserverSetMappingMapper>();
            _curveChartMapper                   = A.Fake <SimulationTimeProfileChartMapper>();
            _processMappingMapper               = A.Fake <ProcessMappingMapper>();
            _simulationFactory                  = A.Fake <ISimulationFactory>();
            _executionContext                   = A.Fake <IExecutionContext>();
            _simulationModelCreator             = A.Fake <ISimulationModelCreator>();
            _simulationBuildingBlockUpdater     = A.Fake <ISimulationBuildingBlockUpdater>();
            _modelPropertiesTask                = A.Fake <IModelPropertiesTask>();
            _simulationRunner                   = A.Fake <ISimulationRunner>();
            _populationAnalysisChartMapper      = A.Fake <PopulationAnalysisChartMapper>();
            _simulationParameterOriginIdUpdater = A.Fake <ISimulationParameterOriginIdUpdater>();
            _logger             = A.Fake <ILogger>();
            _containerTask      = A.Fake <IContainerTask>();
            _entityPathResolver = A.Fake <IEntityPathResolver>();

            sut = new SimulationMapper(_solverSettingsMapper, _outputSchemaMapper,
                                       _outputSelectionMapper, _compoundPropertiesMapper, _parameterMapper,
                                       _advancedParameterMapper, _eventMappingMapper, _observerSetMappingMapper, _curveChartMapper,
                                       _populationAnalysisChartMapper, _processMappingMapper,
                                       _simulationFactory, _executionContext, _simulationModelCreator,
                                       _simulationBuildingBlockUpdater, _modelPropertiesTask,
                                       _simulationRunner, _simulationParameterOriginIdUpdater,
                                       _logger, _containerTask, _entityPathResolver
                                       );

            _project    = new PKSimProject();
            _individual = new Individual {
                Name = "IND", Id = "IND"
            };
            _compound = new Compound {
                Name = "COMP", Id = "COMP"
            };
            _observerSet = new ObserverSet {
                Name = "OBS_SET", Id = "OBS_SET"
            };
            _protocol = new SimpleProtocol {
                Name = "PROT", Id = "PROT"
            };
            _inductionProcess = new InductionProcess().WithName("Interaction process");
            _compound.AddProcess(_inductionProcess);


            _event = new PKSimEvent {
                Name = "Event"
            };
            _population = new RandomPopulation()
            {
                Name = "POP"
            };
            _observedData = new DataRepository("OBS_ID").WithName("OBS");
            _project.AddBuildingBlock(_individual);
            _project.AddBuildingBlock(_compound);
            _project.AddBuildingBlock(_event);
            _project.AddBuildingBlock(_population);
            _project.AddBuildingBlock(_observerSet);
            _project.AddObservedData(_observedData);

            _simulationProperties = new SimulationProperties
            {
                ModelProperties = new ModelProperties
                {
                    ModelConfiguration = new ModelConfiguration {
                        ModelName = "4Comp"
                    }
                }
            };
            _interactionSelection = new InteractionSelection {
                ProcessName = _inductionProcess.Name
            };
            _noInteractionSelection = new InteractionSelection {
                MoleculeName = "CYP2D6"
            };

            _simulationProperties.InteractionProperties.AddInteraction(_interactionSelection);
            _simulationProperties.InteractionProperties.AddInteraction(_noInteractionSelection);

            _settings      = new SimulationSettings();
            _rootContainer = new Container().WithName("Sim");
            _model         = new OSPSuite.Core.Domain.Model {
                Root = _rootContainer
            };

            _individualSimulation = new IndividualSimulation
            {
                Name               = "S1",
                Properties         = _simulationProperties,
                SimulationSettings = _settings,
                Description        = "Simulation Description",
                Model              = _model
            };

            _simulationTimeProfile         = new SimulationTimeProfileChart();
            _snapshotSimulationTimeProfile = new CurveChart();
            _individualSimulation.AddAnalysis(_simulationTimeProfile);

            A.CallTo(() => _curveChartMapper.MapToSnapshot(_simulationTimeProfile)).Returns(_snapshotSimulationTimeProfile);


            _populationSimulation = new PopulationSimulation
            {
                Properties         = _simulationProperties,
                SimulationSettings = _settings,
                Model = _model
            };

            _advancedParameterCollection       = new AdvancedParameterCollection();
            _populationSimulationAnalysisChart = new BoxWhiskerAnalysisChart();
            _populationSimulation.SetAdvancedParameters(_advancedParameterCollection);
            _populationSimulation.AddAnalysis(_populationSimulationAnalysisChart);
            _populationSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndTemplateId", PKSimBuildingBlockType.Individual)
            {
                BuildingBlock = _individual
            });

            _snapshotPopulationAnalysisChart = new Snapshots.PopulationAnalysisChart();

            A.CallTo(() => _populationAnalysisChartMapper.MapToSnapshot(_populationSimulationAnalysisChart)).Returns(_snapshotPopulationAnalysisChart);

            _snapshotInteraction = new CompoundProcessSelection();
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_interactionSelection)).Returns(_snapshotInteraction);
            _snapshotInteraction.CompoundName = _compound.Name;
            _snapshotInteraction.Name         = _inductionProcess.Name;

            _noSelectionSnapshotInteraction = new CompoundProcessSelection();
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_noInteractionSelection)).Returns(_noSelectionSnapshotInteraction);
            _noSelectionSnapshotInteraction.MoleculeName = _noInteractionSelection.MoleculeName;

            _compoundProperties         = new CompoundProperties();
            _snapshotCompoundProperties = new Snapshots.CompoundProperties {
                Name = _compound.Name
            };
            _individualSimulation.Properties.AddCompoundProperties(_compoundProperties);

            _eventMapping = new EventMapping();
            _individualSimulation.EventProperties.AddEventMapping(_eventMapping);

            _observerSetMapping = new ObserverSetMapping();
            _individualSimulation.ObserverSetProperties.AddObserverSetMapping(_observerSetMapping);

            A.CallTo(() => _compoundPropertiesMapper.MapToSnapshot(_compoundProperties, _project)).Returns(_snapshotCompoundProperties);


            _eventSelection = new EventSelection
            {
                Name = _event.Name,
            };

            _observerSetSelection = new ObserverSetSelection
            {
                Name = _observerSet.Name,
            };

            _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndTemplateId", PKSimBuildingBlockType.Individual)
            {
                BuildingBlock = _individual,

                Altered = true
            });

            _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompTemplateId", PKSimBuildingBlockType.Compound)
            {
                BuildingBlock = _compound
            });

            _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("ProtTemplateId", PKSimBuildingBlockType.Protocol)
            {
                BuildingBlock = _protocol
            });

            _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("ObserveSetTemplateId", PKSimBuildingBlockType.ObserverSet)
            {
                BuildingBlock = _observerSet
            });

            _populationSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("PopTemplateId", PKSimBuildingBlockType.Population)
            {
                BuildingBlock = _population
            });


            _individualSimulation.AddUsedObservedData(_observedData);

            A.CallTo(() => _eventMappingMapper.MapToSnapshot(_eventMapping, _project)).Returns(_eventSelection);
            A.CallTo(() => _observerSetMappingMapper.MapToSnapshot(_observerSetMapping, _project)).Returns(_observerSetSelection);

            _outputSelectionSnapshot = new OutputSelections();
            A.CallTo(() => _outputSelectionMapper.MapToSnapshot(_individualSimulation.OutputSelections)).Returns(_outputSelectionSnapshot);

            A.CallTo(() => _processMappingMapper.MapToModel(_snapshotInteraction, _inductionProcess)).Returns(_interactionSelection);

            return(_completed);
        }
Beispiel #19
0
        protected override void Context()
        {
            _view = A.Fake <IBuildingBlockExplorerView>();
            A.CallTo(() => _view.TreeView).Returns(A.Fake <IUxTreeView>());
            _regionResolver = A.Fake <IRegionResolver>();
            _region         = A.Fake <IRegion>();
            A.CallTo(() => _regionResolver.RegionWithName(RegionNames.BuildingBlockExplorer)).Returns(_region);
            _project = new PKSimProject();
            var compound = new Compound().WithName("compound");

            _individual            = new Individual().WithName("individual");
            _individual.OriginData = new OriginData {
                Species = new Species()
            };
            _project.AddBuildingBlock(_individual);
            _project.AddBuildingBlock(compound);
            _observedDataInExplorerPresenter = A.Fake <IObservedDataInExplorerPresenter>();
            _buildingBlockIconRetriever      = A.Fake <IBuildingBlockIconRetriever>();
            _treeNodeFactory                    = A.Fake <ITreeNodeFactory>();
            _contextMenuFactory                 = A.Fake <ITreeNodeContextMenuFactory>();
            _buildingBlockTask                  = A.Fake <IBuildingBlockTask>();
            _toolTipCreator                     = A.Fake <IToolTipPartCreator>();
            _projectRetriever                   = A.Fake <IProjectRetriever>();
            _classificationPresenter            = A.Fake <IClassificationPresenter>();
            _multipleTreeNodeContextMenuFactory = A.Fake <IMultipleTreeNodeContextMenuFactory>();
            sut = new BuildingBlockExplorerPresenter(_view, _treeNodeFactory, _contextMenuFactory, _multipleTreeNodeContextMenuFactory, _buildingBlockIconRetriever, _regionResolver,
                                                     _buildingBlockTask, _toolTipCreator, _projectRetriever, _classificationPresenter, _observedDataInExplorerPresenter);

            _compoundFolderNode    = new RootNode(PKSimRootNodeTypes.CompoundFolder);
            _individualFolderNode  = new RootNode(PKSimRootNodeTypes.IndividualFolder);
            _formulationFolderNode = new RootNode(PKSimRootNodeTypes.FormulationFolder);
            _protocolFolderNode    = new RootNode(PKSimRootNodeTypes.ProtocolFolder);
            _observersFolderNode   = new RootNode(PKSimRootNodeTypes.ObserverSetFolder);
            _populationFolderNode  = new RootNode(PKSimRootNodeTypes.PopulationFolder);
            _eventRootNode         = new RootNode(PKSimRootNodeTypes.EventFolder);
            _simulationNode        = new SimulationNode(new ClassifiableSimulation {
                Subject = new IndividualSimulation {
                    Id = "1"
                }
            });
            _compoundNode        = new ObjectWithIdAndNameNode <Compound>(compound);
            _individualNode      = new ObjectWithIdAndNameNode <Individual>(_individual);
            _observationRootNode = new RootNode(RootNodeTypes.ObservedDataFolder);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.CompoundFolder)).Returns(_compoundFolderNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.IndividualFolder)).Returns(_individualFolderNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.ProtocolFolder)).Returns(_protocolFolderNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.ObserverSetFolder)).Returns(_observersFolderNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.FormulationFolder)).Returns(_formulationFolderNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.PopulationFolder)).Returns(_populationFolderNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(RootNodeTypes.ObservedDataFolder)).Returns(_observationRootNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(PKSimRootNodeTypes.EventFolder)).Returns(_eventRootNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(_individual)).Returns(_individualNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(compound)).Returns(_compoundNode);

            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.CompoundFolder.Id)).Returns(_compoundFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.IndividualFolder.Id)).Returns(_individualFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.ProtocolFolder.Id)).Returns(_protocolFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.ObserverSetFolder.Id)).Returns(_observersFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.FormulationFolder.Id)).Returns(_formulationFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.PopulationFolder.Id)).Returns(_populationFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(RootNodeTypes.ObservedDataFolder.Id)).Returns(_observationRootNode);
            A.CallTo(() => _view.TreeView.NodeById(PKSimRootNodeTypes.EventFolder.Id)).Returns(_eventRootNode);

            A.CallTo(() => _view.AddNode(A <ITreeNode> ._)).ReturnsLazily(s => s.Arguments[0].DowncastTo <ITreeNode>());
        }
Beispiel #20
0
        protected override Task Context()
        {
            _classificationMapper          = A.Fake <ClassificationMapper>();
            _snapshotMapper                = A.Fake <ISnapshotMapper>();
            _executionContext              = A.Fake <IExecutionContext>();
            _lazyLoadTask                  = A.Fake <ILazyLoadTask>();
            _simulationMapper              = A.Fake <SimulationMapper>();
            _simulationComparisonMapper    = A.Fake <SimulationComparisonMapper>();
            _parameterIdentificationMapper = A.Fake <ParameterIdentificationMapper>();
            _classificationSnapshotTask    = A.Fake <IClassificationSnapshotTask>();
            _qualificationPlanMapper       = A.Fake <QualificationPlanMapper>();
            _creationMetaDataFactory       = A.Fake <ICreationMetaDataFactory>();
            _logger = A.Fake <ILogger>();

            sut = new ProjectMapper(
                _simulationMapper,
                _simulationComparisonMapper,
                _parameterIdentificationMapper,
                _qualificationPlanMapper,
                _executionContext,
                _classificationSnapshotTask,
                _lazyLoadTask,
                _creationMetaDataFactory,
                _logger);


            A.CallTo(() => _executionContext.Resolve <ISnapshotMapper>()).Returns(_snapshotMapper);
            _individual               = new Individual().WithName("IND");
            _compound                 = new Compound().WithName("COMP");
            _event                    = new PKSimEvent().WithName("EVENT");
            _formulation              = new Formulation().WithName("FORM");
            _protocol                 = new SimpleProtocol().WithName("PROTO");
            _population               = new RandomPopulation().WithName("POP");
            _observedData             = new DataRepository().WithName("OD");
            _parameterIdentification  = new OSPSuite.Core.Domain.ParameterIdentifications.ParameterIdentification().WithName("PI").WithId("PI_ID");
            _classifiableObservedData = new ClassifiableObservedData {
                Subject = _observedData
            };
            _classification = new Classification {
                ClassificationType = ClassificationType.ObservedData
            }.WithName("OD Classification");
            _simulationComparison = new IndividualSimulationComparison().WithName("COMP").WithId("SimComp");
            _simulation           = new IndividualSimulation().WithName("IND_SIM").WithId("IndSim");
            _qualificationPlan    = new QualificationPlan().WithName("QP").WithId("QP_ID");
            _project = new PKSimProject();
            _project.AddBuildingBlock(_individual);
            _project.AddBuildingBlock(_compound);
            _project.AddBuildingBlock(_event);
            _project.AddBuildingBlock(_formulation);
            _project.AddBuildingBlock(_protocol);
            _project.AddBuildingBlock(_population);
            _project.AddObservedData(_observedData);
            _project.AddBuildingBlock(_simulation);
            _project.AddClassifiable(_classifiableObservedData);
            _project.AddClassification(_classification);
            _project.AddSimulationComparison(_simulationComparison);
            _project.AddParameterIdentification(_parameterIdentification);
            _project.AddQualificationPlan(_qualificationPlan);

            _compoundSnapshot                              = new Snapshots.Compound();
            _individualSnapshot                            = new Snapshots.Individual();
            _eventSnapshot                                 = new Event();
            _formulationSnapshot                           = new Snapshots.Formulation();
            _protocolSnapshot                              = new Snapshots.Protocol();
            _populationSnapshot                            = new Snapshots.Population();
            _observedDataSnapshot                          = new Snapshots.DataRepository();
            _parameterIdentificationSnapshot               = new ParameterIdentification();
            _observedDataClassificationSnapshot            = new Snapshots.Classification();
            _simulationComparisonSnapshot                  = new SimulationComparison();
            _simulationClassificationSnapshot              = new Snapshots.Classification();
            _comparisonClassificationSnapshot              = new Snapshots.Classification();
            _parameterIdentificationClassificationSnapshot = new Snapshots.Classification();
            _qualificationPlanClassificationSnapshot       = new Snapshots.Classification();
            _qualificationPlanSnapshot                     = new Snapshots.QualificationPlan();
            _simulationSnapshot                            = new Simulation();


            A.CallTo(() => _snapshotMapper.MapToSnapshot(_compound)).Returns(_compoundSnapshot);
            A.CallTo(() => _snapshotMapper.MapToSnapshot(_individual)).Returns(_individualSnapshot);
            A.CallTo(() => _snapshotMapper.MapToSnapshot(_event)).Returns(_eventSnapshot);
            A.CallTo(() => _snapshotMapper.MapToSnapshot(_formulation)).Returns(_formulationSnapshot);
            A.CallTo(() => _snapshotMapper.MapToSnapshot(_protocol)).Returns(_protocolSnapshot);
            A.CallTo(() => _snapshotMapper.MapToSnapshot(_population)).Returns(_populationSnapshot);
            A.CallTo(() => _snapshotMapper.MapToSnapshot(_observedData)).Returns(_observedDataSnapshot);
            A.CallTo(() => _simulationMapper.MapToSnapshot(_simulation, _project)).Returns(_simulationSnapshot);
            A.CallTo(() => _simulationComparisonMapper.MapToSnapshot(_simulationComparison)).Returns(_simulationComparisonSnapshot);
            A.CallTo(() => _parameterIdentificationMapper.MapToSnapshot(_parameterIdentification, _project)).Returns(_parameterIdentificationSnapshot);
            A.CallTo(() => _qualificationPlanMapper.MapToSnapshot(_qualificationPlan)).Returns(_qualificationPlanSnapshot);

            A.CallTo(() => _classificationSnapshotTask.MapClassificationsToSnapshots <ClassifiableObservedData>(_project)).Returns(new[] { _observedDataClassificationSnapshot });
            A.CallTo(() => _classificationSnapshotTask.MapClassificationsToSnapshots <ClassifiableSimulation>(_project)).Returns(new[] { _simulationClassificationSnapshot });
            A.CallTo(() => _classificationSnapshotTask.MapClassificationsToSnapshots <ClassifiableComparison>(_project)).Returns(new[] { _comparisonClassificationSnapshot });
            A.CallTo(() => _classificationSnapshotTask.MapClassificationsToSnapshots <ClassifiableParameterIdentification>(_project)).Returns(new[] { _parameterIdentificationClassificationSnapshot });
            A.CallTo(() => _classificationSnapshotTask.MapClassificationsToSnapshots <ClassifiableQualificationPlan>(_project)).Returns(new[] { _qualificationPlanClassificationSnapshot });

            return(_completed);
        }
Beispiel #21
0
        protected override Task Context()
        {
            _calculationMethodCacheMapper = A.Fake <CalculationMethodCacheMapper>();
            _processMappingMapper         = A.Fake <ProcessMappingMapper>();
            _logger  = A.Fake <ILogger>();
            _project = new PKSimProject();
            _calculationMethodSnapshot = new CalculationMethodCache();
            sut = new CompoundPropertiesMapper(_calculationMethodCacheMapper, _processMappingMapper, _logger);

            _compoundGroupSelectionOneAlternative = new CompoundGroupSelection
            {
                AlternativeName = "ALT1",
                GroupName       = "ALTERNATIVE_GROUP_1"
            };

            _compoundGroupSelectionTwoAlternatives = new CompoundGroupSelection
            {
                AlternativeName = "ALT2",
                GroupName       = "ALTERNATIVE_GROUP_2"
            };

            _compound = new Compound
            {
                Name = "COMP",
            };

            _protocol = new SimpleProtocol
            {
                Name = "PROTOCOL"
            };

            _parameterAlternativeGroupWithOneAlternative = new ParameterAlternativeGroup {
                Name = _compoundGroupSelectionOneAlternative.GroupName
            };
            _parameterAlternativeGroupWithTwoAlternatives = new ParameterAlternativeGroup {
                Name = _compoundGroupSelectionTwoAlternatives.GroupName
            };

            _parameterAlternativeGroupWithTwoAlternatives.AddAlternative(new ParameterAlternative {
                Name = "ALT1"
            });
            _parameterAlternativeGroupWithTwoAlternatives.AddAlternative(new ParameterAlternative {
                Name = "ALT2"
            });

            _compound.AddParameterAlternativeGroup(_parameterAlternativeGroupWithOneAlternative);
            _compound.AddParameterAlternativeGroup(_parameterAlternativeGroupWithTwoAlternatives);

            _compoundProperties = new Model.CompoundProperties();

            _compoundProperties.AddCompoundGroupSelection(_compoundGroupSelectionOneAlternative);
            _compoundProperties.AddCompoundGroupSelection(_compoundGroupSelectionTwoAlternatives);
            _compoundProperties.Compound = _compound;
            _enzymaticProcess            = new EnzymaticProcess {
                Name = "EnzymaticProcess"
            };
            _anotherEnzymaticProcess = new EnzymaticProcess {
                Name = "AnotherEnzymaticProcess", MoleculeName = "CYP3A4"
            };
            _specificBindingProcess = new SpecificBindingPartialProcess {
                Name = "SpecificBinding"
            };
            _gfrTransportProcess = new SystemicProcess {
                Name = "Transport", SystemicProcessType = SystemicProcessTypes.GFR
            };
            _hepaticEnzymaticProcess = new SystemicProcess {
                Name = "Plasma Clearance", SystemicProcessType = SystemicProcessTypes.Hepatic
            };
            _compound.AddProcess(_enzymaticProcess);
            _compound.AddProcess(_specificBindingProcess);
            _compound.AddProcess(_gfrTransportProcess);
            _compound.AddProcess(_hepaticEnzymaticProcess);

            _enzymaticPartialProcessSelection = new EnzymaticProcessSelection {
                ProcessName = _enzymaticProcess.Name
            };
            _noEnzymaticSystemicProcessSelection = new SystemicProcessSelection {
                ProcessType = SystemicProcessTypes.Hepatic
            };
            _specificBindingPartialProcessSelection = new ProcessSelection {
                ProcessName = _specificBindingProcess.Name
            };
            _transportSystemicProcessSelection = new SystemicProcessSelection {
                ProcessName = _gfrTransportProcess.Name, ProcessType = _gfrTransportProcess.SystemicProcessType,
            };
            _noEnzymaticPartialProcessSelection = new EnzymaticProcessSelection {
                MoleculeName = _anotherEnzymaticProcess.MoleculeName
            };
            _compoundProperties.Processes.MetabolizationSelection.AddPartialProcessSelection(_enzymaticPartialProcessSelection);
            _compoundProperties.Processes.MetabolizationSelection.AddPartialProcessSelection(_noEnzymaticPartialProcessSelection);
            _compoundProperties.Processes.MetabolizationSelection.AddSystemicProcessSelection(_noEnzymaticSystemicProcessSelection);
            _compoundProperties.Processes.SpecificBindingSelection.AddPartialProcessSelection(_specificBindingPartialProcessSelection);
            _compoundProperties.Processes.TransportAndExcretionSelection.AddSystemicProcessSelection(_transportSystemicProcessSelection);

            _snapshotProcess1 = new CompoundProcessSelection {
                Name = _enzymaticPartialProcessSelection.ProcessName
            };
            _snapshotProcess2 = new CompoundProcessSelection {
                Name = _specificBindingPartialProcessSelection.ProcessName
            };
            _snapshotProcess3 = new CompoundProcessSelection {
                Name = _transportSystemicProcessSelection.ProcessName
            };
            _snapshotProcess4 = new CompoundProcessSelection {
                SystemicProcessType = _noEnzymaticSystemicProcessSelection.ProcessType.SystemicProcessTypeId.ToString()
            };
            _snapshotProcess5 = new CompoundProcessSelection {
                MoleculeName = _noEnzymaticPartialProcessSelection.MoleculeName
            };

            _formulation = new Formulation
            {
                Id = "123456"
            };
            _compoundProperties.ProtocolProperties.Protocol = _protocol;
            _compoundProperties.ProtocolProperties.AddFormulationMapping(new FormulationMapping
            {
                FormulationKey        = "F1",
                TemplateFormulationId = _formulation.Id
            });

            _project.AddBuildingBlock(_formulation);
            A.CallTo(() => _calculationMethodCacheMapper.MapToSnapshot(_compoundProperties.CalculationMethodCache)).Returns(_calculationMethodSnapshot);
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_enzymaticPartialProcessSelection)).Returns(_snapshotProcess1);
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_specificBindingPartialProcessSelection)).Returns(_snapshotProcess2);
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_transportSystemicProcessSelection)).Returns(_snapshotProcess3);
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_noEnzymaticSystemicProcessSelection)).Returns(_snapshotProcess4);
            A.CallTo(() => _processMappingMapper.MapToSnapshot(_noEnzymaticPartialProcessSelection)).Returns(_snapshotProcess5);

            A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess1, _enzymaticProcess)).Returns(_enzymaticPartialProcessSelection);
            A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess2, _specificBindingProcess)).Returns(_specificBindingPartialProcessSelection);
            A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess3, _gfrTransportProcess)).Returns(_transportSystemicProcessSelection);
            A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess4, A <NotSelectedSystemicProcess> ._)).Returns(_noEnzymaticSystemicProcessSelection);
            A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess5, A <EnzymaticProcess> ._)).Returns(_noEnzymaticPartialProcessSelection);

            return(_completed);
        }
        protected override void Context()
        {
            _buildingBlockIconRetriever = A.Fake <IBuildingBlockIconRetriever>();
            _view = A.Fake <ISimulationExplorerView>();
            A.CallTo(() => _view.TreeView).Returns(A.Fake <IUxTreeView>());
            _treeNodeFactory    = A.Fake <ITreeNodeFactory>();
            _contextMenuFactory = A.Fake <ITreeNodeContextMenuFactory>();
            _regionResolver     = A.Fake <IRegionResolver>();
            _buildingBlockInSimulationManager = A.Fake <IBuildingBlockInSimulationManager>();
            _buildingBlockTask  = A.Fake <IBuildingBlockTask>();
            _toolTipNodeCreator = A.Fake <IToolTipPartCreator>();
            _projectRetriever   = A.Fake <IProjectRetriever>();
            _multipleTreeNodeContextMenuFactory      = A.Fake <IMultipleTreeNodeContextMenuFactory>();
            _parameterAnalysablesInExplorerPresenter = A.Fake <IParameterAnalysablesInExplorerPresenter>();
            _simulationComparisonTask = A.Fake <ISimulationComparisonTask>();
            _simulationFolderNode     = new RootNode(RootNodeTypes.SimulationFolder);
            _comparisonFolderNode     = new RootNode(RootNodeTypes.ComparisonFolder);
            _project          = new PKSimProject();
            _usedObservedData = new UsedObservedData {
                Id = "UsedData"
            };
            _simulation           = new IndividualSimulation().WithName("individualSimulation").WithId("individualSimulation");
            _populationSimulation = new PopulationSimulation().WithName("populationSimulation").WithId("populationSimulation");
            _importedSimulaton    = A.Fake <Simulation>().WithName("ImportedSimulation").WithId("ImportedSimulation");
            A.CallTo(() => _importedSimulaton.IsImported).Returns(true);
            _simulation.Properties                   = new SimulationProperties();
            _simulation.ModelProperties              = new ModelProperties();
            _simulation.ModelConfiguration           = A.Fake <ModelConfiguration>();
            _populationSimulation.Properties         = new SimulationProperties();
            _populationSimulation.ModelProperties    = new ModelProperties();
            _populationSimulation.ModelConfiguration = A.Fake <ModelConfiguration>();
            _classificationPresenter                 = A.Fake <IClassificationPresenter>();
            _project.AddBuildingBlock(_simulation);
            _project.AddBuildingBlock(_populationSimulation);
            var classifiableIndividualSimulation = new ClassifiableSimulation {
                Subject = _simulation
            };
            var classfiablePopulationSimulation = new ClassifiableSimulation {
                Subject = _populationSimulation
            };
            var classifiableImportSimulation = new ClassifiableSimulation {
                Subject = _importedSimulaton
            };

            _project.AddClassifiable(classifiableIndividualSimulation);
            _project.AddClassifiable(classfiablePopulationSimulation);
            _individualSimulationNode = new SimulationNode(classifiableIndividualSimulation);
            _populationSimulationNode = new SimulationNode(classfiablePopulationSimulation);
            _importedSimulationNode   = new SimulationNode(classifiableImportSimulation);
            _usedObservedDataNode     = A.Fake <ITreeNode>();
            A.CallTo(() => _treeNodeFactory.CreateFor(classifiableIndividualSimulation)).Returns(_individualSimulationNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(classfiablePopulationSimulation)).Returns(_populationSimulationNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(classifiableImportSimulation)).Returns(_importedSimulationNode);
            A.CallTo(() => _treeNodeFactory.CreateFor(_usedObservedData)).Returns(_usedObservedDataNode);
            _project.AddBuildingBlock(_importedSimulaton);

            var simulationComparison   = A.Fake <ISimulationComparison>().WithId("SimComp_Id");
            var classifiableComparison = new ClassifiableComparison {
                Subject = simulationComparison
            };

            _comparisonNode = new ComparisonNode(classifiableComparison);
            _project.AddSimulationComparison(simulationComparison);
            A.CallTo(() => _treeNodeFactory.CreateFor(classifiableComparison)).Returns(_comparisonNode);


            _usedCompoundBuildingBlock = new UsedBuildingBlock("toto", PKSimBuildingBlockType.Compound)
            {
                Id = "usedBB"
            };
            _simulation.AddUsedBuildingBlock(_usedCompoundBuildingBlock);
            _simulation.AddUsedObservedData(_usedObservedData);

            _project.AddClassifiable(classifiableComparison);

            _templageCompoundBuildingBlock = A.Fake <IPKSimBuildingBlock>();
            _usedBuildingBlockNode         = new UsedBuildingBlockInSimulationNode(_simulation, _usedCompoundBuildingBlock, _templageCompoundBuildingBlock);
            A.CallTo(() => _treeNodeFactory.CreateFor(_simulation, _usedCompoundBuildingBlock)).Returns(_usedBuildingBlockNode);
            A.CallTo(() => _buildingBlockIconRetriever.IconFor(_simulation)).Returns(ApplicationIcons.SimulationGreen);
            A.CallTo(() => _buildingBlockIconRetriever.IconFor(_populationSimulation)).Returns(ApplicationIcons.SimulationGreen);
            A.CallTo(() => _buildingBlockIconRetriever.IconFor(_usedCompoundBuildingBlock)).Returns(ApplicationIcons.CompoundRed);
            A.CallTo(() => _view.TreeView.NodeById(_simulation.Id)).Returns(_individualSimulationNode);
            A.CallTo(() => _view.TreeView.NodeById(_usedCompoundBuildingBlock.Id)).Returns(_usedBuildingBlockNode);
            A.CallTo(() => _view.TreeView.NodeById(RootNodeTypes.SimulationFolder.Id)).Returns(_simulationFolderNode);
            A.CallTo(() => _view.TreeView.NodeById(RootNodeTypes.ComparisonFolder.Id)).Returns(_comparisonFolderNode);

            _observedDataInSimulationManager = A.Fake <IObservedDataInSimulationManager>();
            sut = new SimulationExplorerPresenter(
                _view, _treeNodeFactory, _contextMenuFactory,
                _multipleTreeNodeContextMenuFactory, _buildingBlockIconRetriever,
                _regionResolver, _buildingBlockTask, _buildingBlockInSimulationManager,
                _toolTipNodeCreator, _projectRetriever, _classificationPresenter,
                _parameterAnalysablesInExplorerPresenter, _observedDataInSimulationManager, _simulationComparisonTask);

            A.CallTo(() => _projectRetriever.CurrentProject).Returns(_project);
        }
Beispiel #23
0
 public void should_add_the_new_simulation_to_the_project()
 {
     A.CallTo(() => _project.AddBuildingBlock(_newSimulation)).MustHaveHappened();
 }