public ISimulation CreateWithCalculationMethodsFrom(ISimulation templateSimulation, IEnumerable <CalculationMethodWithCompoundName> combination)
{
var simulation = templateSimulation.DowncastTo <IndividualSimulation>();
var newSimulation = createModelLessSimulationBasedOn(simulation);
combination.GroupBy(x => x.CompoundName).Each(grouping =>
{
replaceCalculationMethodsWithNewCalculationMethods(grouping, newSimulation.CompoundPropertiesFor(grouping.Key));
});
_simulationModelCreator.CreateModelFor(newSimulation);
return(newSimulation);
}
public override void UpdateAppliedDose(ISimulation simulation, string moleculeName, PKCalculationOptions options, IReadOnlyList <ApplicationParameters> allApplicationParameters)
{
base.UpdateAppliedDose(simulation, moleculeName, options, allApplicationParameters);
if (options.SingleDosing)
{
return;
}
//we have at least 2 applied applications at that stage since we are in multiple dosing mode
var bodyWeight = simulation.DowncastTo <Simulation>().BodyWeight?.Value;
var applicationCount = allApplicationParameters.Count;
options.FirstDose = drugMassPerBodyWeightFor(allApplicationParameters[0].DrugMass, bodyWeight);
options.LastMinusOneDose = drugMassPerBodyWeightFor(allApplicationParameters[applicationCount - 2].DrugMass, bodyWeight);
options.LastDose = drugMassPerBodyWeightFor(allApplicationParameters[applicationCount - 1].DrugMass, bodyWeight);
}
public ICommand UpdateParameterValueOrigin(IParameter parameter, ValueOrigin valueOrigin, ISimulation simulation)
{
return(_quantityTask.UpdateQuantityValueOriginInSimulation(parameter, valueOrigin, simulation.DowncastTo <IMoBiSimulation>()));
}
public ICommand SetParameterValue(IParameter parameter, double value, ISimulation simulation)
{
return(_quantityTask.SetQuantityBaseValue(parameter, value, simulation.DowncastTo <IMoBiSimulation>()));
}