protected override void Context()
{
_vssCalculator = A.Fake <IVSSCalculator>();
_parameterFactory = A.Fake <IParameterFactory>();
_protocolMapper = A.Fake <IProtocolToSchemaItemsMapper>();
_protocolFactory = A.Fake <IProtocolFactory>();
_globalPKAnalysisRunner = A.Fake <IGlobalPKAnalysisRunner>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkAnalysisTask = A.Fake <IPKAnalysesTask>();
_interactionTask = A.Fake <IInteractionTask>();
_cloner = A.Fake <ICloner>();
sut = new GlobalPKAnalysisTask(_parameterFactory, _protocolMapper, _protocolFactory, _globalPKAnalysisRunner,
_pkAnalysisTask, _pkCalculationOptionsFactory, _vssCalculator, _interactionTask, _cloner);
var baseGrid = new BaseGrid("time", A.Fake <IDimension>());
_peripheralVenousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, _compoundName);
_venousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.VENOUS_BLOOD, CoreConstants.Compartment.PLASMA, CoreConstants.Observer.CONCENTRATION_IN_CONTAINER, _compoundName);
_individual = A.Fake <Individual>();
_species = new Species();
A.CallTo(() => _individual.Species).Returns(_species);
_compound = new Compound().WithName(_compoundName);
_compoundProperties = new CompoundProperties {
Compound = _compound
};
_protocol = new SimpleProtocol();
_compoundProperties.ProtocolProperties.Protocol = _protocol;
_simulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_simulation.Properties.AddCompoundProperties(_compoundProperties);
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompId", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndividualId", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.DataRepository = new DataRepository {
_venousBloodPlasma, _peripheralVenousBloodPlasma
};
_simulation.SimulationSettings = new SimulationSettings();
_simulation.OutputSchema = new OutputSchema();
_simulation.OutputSchema.AddInterval(new OutputInterval {
DomainHelperForSpecs.ConstantParameterWithValue(100).WithName(Constants.Parameters.END_TIME)
});
_simulation.Model = new OSPSuite.Core.Domain.Model {
Root = new Container()
};
_eventGroup = new EventGroup();
_application1 = new Container().WithName("App1").WithContainerType(ContainerType.Application);
_application1.Add(new MoleculeAmount().WithName(_compoundName));
_application1.Add(DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.START_TIME));
_application2 = new Container().WithName("App2").WithContainerType(ContainerType.Application);
_application2.Add(DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.START_TIME));
_application2.Add(new MoleculeAmount().WithName(_compoundName));
_simulation.Model.Root.Add(_eventGroup);
_eventGroup.Add(_application1);
_venousBloodPK = new PKValues();
_venousBloodPK.AddValue(Constants.PKParameters.Vss, 10);
_venousBloodPK.AddValue(Constants.PKParameters.Vd, 11);
_venousBloodPK.AddValue(Constants.PKParameters.CL, 12);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 13);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 14);
_peripheralVenousBloodPK = new PKValues();
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vss, 21);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vd, 22);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.CL, 23);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 24);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 25);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max, 26);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max_tDLast_tDEnd, 27);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_venousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_venousBloodPK);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_peripheralVenousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_peripheralVenousBloodPK);
A.CallTo(() => _parameterFactory.CreateFor(A <string> ._, A <double> ._, A <string> ._, PKSimBuildingBlockType.Simulation))
.ReturnsLazily(s => new PKSimParameter().WithName((string)s.Arguments[0])
.WithDimension(A.Fake <IDimension>())
.WithFormula(new ConstantFormula((double)s.Arguments[1])));
}