This is a GUI for AVRDUDE (http://savannah.nongnu.org/projects/avrdude).
http://blog.zakkemble.co.uk/avrdudess-a-gui-for-avrdude/
Requires .NET Framework 2.0 SP1 or newer (http://www.microsoft.com/en-gb/download/details.aspx?id=16614). Latest .NET can be found here - http://www.microsoft.com/net
AVRDUDE requires LibUSB LibUSB should really be installed the normal way as a driver for a LibUSB device, but if you don't have any such devices then you will need to download this - http://downloads.sourceforge.net/libusb-win32/libusb-win32-bin-1.2.6.0.zip
Extract libusb-win32-bin-1.2.6.0/bin/x86/libusb_x86.dll to where you have avrdude.exe placed and rename libusb_x86.dll to libusb.dll
Can be ran using Mono (http://www.mono-project.com).
Has not been tested on OS X, but should work.
Install Mono (this is the minimum required, you can do mono-complete for a full install)
sudo apt-get install libmono-winforms2.0-cil
Install AVRDUDE
sudo apt-get install avrdude
Run AVRDUDESS with mono, you might have to run as root (sudo) so AVRDUDE runs as root if you havn't changed any rules.d stuff
mono avrdudess.exe
Zak Kemble