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MultiAlign

MultiAlign aligns multiple LC-MS datasets to one another after which LC-MS features can be matched to a database of peptides (typically an AMT tag database). The program reads deisotoped features from either DeconTools or ICR-2LS. The LC-MS/MS Accurate Mass and Time Tag database is a SQLite file, typically generated by MTDB Creator.

The MultiAlign application provides advanced visualization and manipulation capabilities for LC-MS datasets acquired on high resolution mass spectrometers. Functionalities include overlaid 2D plots, alignment plots, normalizations, and basic statistical comparisons. MultiAlign uses the LCMSWARP algorithm to align LC-MS datasets to a master list (mass tag database or a single LC-MS dataset) and then consolidate features into a consensus map. These features can be matched to an AMT tag database to identify the LC-MS features. Data processing is similar to that performed with the VIPER application, but MultiAlign has the advantage of finding consensus features followed by matching to an AMT tag DB. The processing performed by MultiAlign results in fewer "missing values" vs. the results obtained when analyzing separate datasets with VIPER.

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Aligns multiple LC-MS datasets to one another after which LC-MS features can be matched to a database of peptides (typically an AMT tag database)

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